摘要
目的观察抗肿瘤药物丝裂霉素（ＭＭＣ）、西艾克（ＶＤＳ）和顺铂（ＤＤＰ）组成的ＭＶＰ方案或西艾克加顺铂组成的ＶＰ方案治疗晚期非小细胞肺癌（ＮＳＣＬＣ）的近期疗效和毒性。方法治疗晚期非小细胞肺癌５７例，用ＭＶＰ方案治疗３０例，用ＶＰ方案治疗２７例。ＭＭＣ６ｍｇ／ｍ２静推第１天；ＶＤＳ３ｍｇ／ｍ２静推第１、第５天或第１、第８天；ＤＤＰ４０ｍｇ静滴第１～３天。计算有效率、毒性，χ２和Ｐ值，并以此来判断两组方案的优越性。结果有效率ＭＶＰ组为５０％，ＶＰ组为４４４％，两组比较有效率相近（χ２＝０．１７６，Ｐ＞００５）。毒性反应主要为骨髓抑制，且以白细胞和血小板下降明显。ＭＶＰ组白细胞下降占９６７％，Ⅲ～Ⅳ级毒性占４６７％；ＶＰ组白细胞下降占８８８％，Ⅲ～Ⅳ级毒性占４０７％。ＭＶＰ组血小板下降占９０％，Ⅲ～Ⅳ级毒性占２３３％；ＶＰ组血小板下降占５５５％，Ⅲ级毒性占７４％，前者较后者更为严重（χ２＝８．６９５，Ｐ＜００１）。其次为胃肠道毒性和脱发，二组相仿，均为Ⅰ～Ⅱ级。结论ＭＶＰ和ＶＰ方案是治疗晚期非小细胞肺癌的有效方案，但ＭＶＰ组的骨髓抑制较ＶＰ组更为严重，因此治疗晚期非小细胞肺癌以ＶＰ方案更为理想?
Objective This study is to observe the effect and toxicity of mitomycin,vindesine and cisplatin(MVP) versus vindesine and cisplatin(VP) in the treatment of advanced non-small cell lung cancer.Methods 57 patients with advanced non-small cell lung cancer were divided into two groups including 30 treated with MVP regimen and 27 treated with VP regimen.Mitomycin was given 6mg/m 2 iv on day 1,Videsine 3mg/m 2 iv on day 1,5 or on day 1,8,Cisplatin 40mg iv drip on day 1～3.Results The response rates were 50% in group of MVP and 44.4% in group of VP respectively.There was no statistical difference between the two groups(χ 2=0.176, P >0.05) Main toxicity was myelosuppression including apparent decrease of white blood cell and platelets.In MVP group,96.7% patients had leukocytopenia including 46.7% of Ⅲ～Ⅳ degrees,and 90% of patients had thrombocytopenia including 23.3% of Ⅲ～Ⅳ degrees.In VP group,88.8% of patients had leukopenia including 40.7% of Ⅲ～Ⅳ degrees,and 55.5% had thrombocytopenia including 7.4% of Ⅲ～Ⅳ degrees which was milder than that in MVP group(χ 2=8.695, P <0.01).Other toxicity included gastrointestinal reaction and alopecia and were similar in both groups.Conclusions MVP regimen and VP regimen were both effective in advanced nonsmall cell lung cancer.However myelossuppression was more severe in group of MVP than that in VP group.Therefore VP regimen were more preferable in the treatment of advanced non small cell lung cancer.
出处
《河南肿瘤学杂志》
1999年第1期32-34,共3页
Henan Journal of Oncology
