摘要
对淀粉微球致孔方法及多孔淀粉微球的应用性能进行了研究,首先确定了微球制备的基本条件并且进行了优化。用于制备淀粉微球的最佳条件为:玉米淀粉质量分数为5%,交联剂用量0.28g/g,乳化剂用量为0.05g/mL,油水相体积比3∶1,机械搅拌速度600r/min,由这些因素组成了油包水反相乳液体系。在此基础上,对微球致孔方法进行了研究,分别使用冷冻干燥法和加入致孔剂法对微球致孔,得到了具有多孔结构的微球,通过扫描电子显微镜观察了成孔效果并且研究了不同PEG6000添加量对微球孔隙率的影响。以亚甲基蓝作为模拟药物,研究了多孔微球的药物负载性能,在PEG6000添加量为淀粉质量的30%时,多孔微球的孔隙率为89%,载药量为158mg/g。
The pore-forming method and applied performance of starch microspheres were studied and the preparation conditions of the microspheres were optimized.The optimum conditions were as follow：corn starch concentration of 5%,the dosage of cross-linking agent of 0.28g/g,emulsifier dosage of 0.05g/mL,the volume ratio of oil to water of 3∶1and the agitation rate of 600r/min.The pore-forming method of the microspheres was studied using freeze drying method and adding pore-forming agent PEG,DMPE and PVP to the aqueous phase.The microspheres with porous structure using scanning electron microscope and the influence of different amount of PEG6000 on the porosity was studied.The loading performance of the porous microspheres was studied using methylene blue as a model drug.The porosity of the porous microspheres and the amount of drug loading could reach to 89% and 158mg/g when the amount of pore-forming agent was 30%.
作者
司晓菲
吕继祥
李沅
刘兆丽
孙岩峰
SI Xiaofei LYU Jixiang LI Yuan LIU Zhaoli SUN Yanfeng(School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, China Zhejiang Jihua Group Company Limited, Hangzhou 311234, China)
出处
《大连工业大学学报》
CAS
北大核心
2016年第6期452-456,共5页
Journal of Dalian Polytechnic University
基金
辽宁省科技厅工业攻关计划项目(2011223010)
关键词
淀粉微球
致孔方法
孔隙率
载药量
starch microspheres
method of pore-forming
porosity
drug loading
