摘要
目的探讨肿瘤坏死因子-α（TNF-α）G-308A多态性和自发性早产（SPTB）易感性的关联。方法收集753例SPTB患儿为病例组,681例足月新生儿为对照组,利用Sequenom Mass ARRAY~？SNP检测技术对TNF-α基因G-308A多态性位点进行单核苷酸多态性检测。结果病例组和对照组等位基因G、A分布频率之间的差异无统计学意义（P=0.35）;GG、GA、AA基因型构成比之间的差异也无统计学意义（P=0.64）。Logistic回归分析发现TNF-α基因G-308A位点与SPTB的遗传易感性不相关（OR=0.85,95%CI：0.61~1.19,P=0.35）。结论 TNF-α基因G-308A多态性位点与SPTB遗传易感性不相关。
Objective To study the association between tumor necrosis factor-α（TNF-α） G-308 A polymorphisms and genetic susceptibility to spontaneous preterm birth（SPTB）.Methods The case group enrolled 753 SPTB infants and the control group included 681 term infants.TNF-α G-308 A polymorphisms were genotyped using Sequenom Mass ARRAY？SNP.Results The frequencies of the allele（G and A） in the case and control groups were not significantly different（P=0.35）.The frequencies of the genotypes（GG,GA and AA） in the case and control groups were not significantly different（P=0.64）.The logistic regression analysis found that TNF-α G-308 A was not associated with genetic susceptibility to SPTB（OR=0.85; 95%CI： 0.61-1.19; P=0.35）.Conclusions There is no association between the polymorphisms of TNF-α G-308 A and the genetic susceptibility to SPTB.
作者
彭薇
杨晓
朱丽娜
张小爱
王艳
PENG Wei YANG Xiao ZHU Li-Na ZHANG Xiao-Ai WANG Yah(Bayi Children＇s Hospital Affiliated to Chinese People＇s Liberation Army General Hospital Beijing 100700, China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2016年第12期1247-1253,共7页
Chinese Journal of Contemporary Pediatrics
基金
国家自然科学基金(81300527)
关键词
肿瘤坏死因子-Α
自发性早产
单核苷酸多态性
早产儿
Tumor necrosis factor-α
Spontaneous preterm birth
Single nucleotide polymorphism
Preterm infant
