摘要
目的研究转运蛋白SLC17A3基因V257F点突变与原发性痛风的关系。方法应用TaqMan探针荧光定量PCR技术,对576例散发痛风病人SLC17A3基因进行基因单核苷酸多态性检测。结果 576例散发痛风病人中未发现SLC17A3基因V257F点突变。结论原发性痛风病人的发病与SLC17A3基因V257F点突变无关,显示原发性痛风的遗传异质性。
Objective To study the relationship between the mutation of V257F point in SLC17A3 gene and primary gout. Methods By using TaqMan probe fluorescence PCR, single nucieotide polymorphism of SLC17A3 gene was detected in 576 patients with sporadic gout. Results No mutation was detected on the site of SLC17A3 gene V257F in the patients. Con- clusion The onset of primary gout is not associated with the mutation of V257F point in SLC17A3 gene, indicating the heteroge- neity of heredity of the disease.
出处
《青岛大学医学院学报》
CAS
2013年第1期25-26,共2页
Acta Academiae Medicinae Qingdao Universitatis
基金
国家自然科学青年基金项目(81100621)
山东省自然科学基金项目(ZR2011HM005)
