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冠心病病人ABCA1基因单核苷酸多态性检测的意义 被引量：1

THE SIGNIFICANCE OF ATP-BINDING CASSETTE TRANSPORTER 1 IN PATIENTS WITH CORONARY HEART DISEASE
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摘要 冠心病是威胁人类健康的常见心血管疾病。研究血脂调节基因将对冠心病的防治有重要意义。ABCA1基因的主要功能是:直接或间接介导胆固醇和磷脂通过细胞膜转运到载脂蛋白AI(apoA-I)。其单核苷酸多态性(single nucleotide polymorphism,SNP)变异对其功能有不同的影响。 Coronary heart disease （CHD） is a common cardiovascular disease threatening human health. The studies about the genes of adjusting lipid are significant to the prevention and cure of CHD. The main functions of ABCA1 include that it can mediate transport of cholesterol and phospholipids across cellular membranes to apoA - I either directly or indirectly. The mutations of single nucleotide polymorphism in the ABCAI have various effects on it＇s functions.
作者 王丽 袁托亚 王悦喜
机构地区 内蒙古医学院 内蒙古医学院附属医院心内科
出处 《内蒙古医学院学报》 2008年第5期393-396,共4页 Acta Academiae Medicinae Neimongol
基金 内蒙古自然科学基金项目(200408020930)
关键词 冠心病 ATP结合盒转运体 单核苷酸多态性 coronary heart disease ATP- binding cassette transporter 1 single nucleotide polymorphism
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献22

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二级参考文献49

  • 1赵水平,肖志杰,聂赛,李全忠,谭利民,胡治平,吴军,周宏年.冠心病患者ATP结合盒转运子1基因R219K变异的研究[J].中华心血管病杂志,2004,32(8):712-716. 被引量：18
  • 2孙屏,薄小萍,郭冬平,李晓宇,胡志斌,王君,李肖蓉,范乐明,陈琪.ABCA1基因多态性与冠心病易感性的关联研究[J].中华心血管病杂志,2005,33(7):627-630. 被引量：22
  • 3吴银,白怀,刘瑞,刘宇,刘秉文.中国人内源性高甘油三酯血症患者胆固醇酯转运蛋白基因Taq IB和-629C/A多态性[J].中华医学遗传学杂志,2006,23(6):640-646. 被引量：8
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内蒙古医学院学报
2008年 第5期

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