摘要
目的：了解深圳地区不同类型慢性肝炎人群戊型病毒性肝炎（简称戊肝，HE）的流行现状，为戊肝的预防和治疗提供科学依据。方法随机选择2013年7月-2015年6月来本院体检及就诊的无肝炎人群1746例为对照组，同时选择慢性乙型病毒性肝炎（简称乙肝）患者1320例，慢性丙型病毒性肝炎（简称丙肝）患者615例，分别应用酶联免疫吸附试验（ELISA）法检测血清戊肝抗体-IgG（抗HEV-IgG），分析和比较不同类型肝炎人群戊肝流行情况。结果1746例对照组血清抗HEV-IgG阳性率为3.49%（61/1746），其中男性4.22%（39/925），女性2.68%（22/821）；1320例乙肝组抗HEV-IgG阳性率为10.9%（144/1320），其中男性12.29%（93/700），女性8.23%（51/620）；615例丙肝组抗HEV-IgG阳性率为10.2%（63/615），其中男性12.35%（42/340），女性7.64%（21/275）。乙肝组和丙肝组抗HEV-IgG阳性率与对照组比较差异有统计学意义（χ^2=9.163-9.405，P〈0.05），乙肝组与丙肝组抗HEV-IgG阳性率的差异无统计学意义（χ^2=0.614，P〉0.05），戊肝以男性流行率高于女性，差异有统计学意义（χ^2=2.873-4.025，P〈0.05）。结论慢性乙型和丙型病毒性肝炎人群抗HEV-IgG阳性率高于无肝炎人群，戊肝流行率以男性高于女性。因此，开展对慢性肝炎人群的早发现、早诊断和早治疗，对降低戊肝流行率具有重要的意义。
ObjectiveTo understand the epidemic status of anti-HEV IgG antibody prevalence among different types of chronic hepatitis in Shenzhen,and provide evidence of hepatitis E for its prevention and treatment.Methods 1746 cases were randomly collected in physical examination and doctor visiting as control from July2013 to June2015. Simultaniously,1320 cases of positive HBVand615 cases of positive HCV were detected. ELISAwas used to detect serum HEV IgG antibodies-（anti-HEV-IgG）.Result The positive rate of1746 cases of control group in serum anti-HEV-IgG was3.49%（61/1746） and4.22%（39/925）in men,and2.68%（22/821）in women,while1320 cases of HBV showed the prevalence of10.9%（144/1320）and12.29%（93/700）in men and8.23%（51/620）in women,and615 cases of HCV indictated positive rates of10.2%（63/615） and12.35%（42/340） in men and7.64%（21/275） in women. A significant difference was seen between HBV/HCV and the group of control.（χ^2=9.163~9.405,P〈0.05）. No obvious difference was found between HBV and HCV groups for positive anti-HEV-IgG（χ^2=0.614,P〉0.614）.The prevalence of HEV was higher in men than that in women（χ^2=2.873~4.025,P〈0.05）.Conclusion The positive rate of anti-HEV-IgG in the individuals of chronic Hepatitis B and Hepatitis C is higher than that of normal population,and HEV positive rate of men is higher than that of women. Early diagnosis and treatment ofthe patients with chronic hepatitis B and Hepatitis C are significant in reducinghepatitis epidemic.
出处
《临床输血与检验》
CAS
2016年第6期590-592,共3页
Journal of Clinical Transfusion and Laboratory Medicine
