摘要
中枢神经系统的损伤和神经退行性疾病的移植治疗需要重要的细胞来源。如今,细胞来源的研究主要集中于诱导多功能干细胞(i PSCs)技术和体细胞直接转分化技术。现已有多种方式实现了高效诱导神经元的转化和成熟,而且从安全性角度考虑,转化方式也正逐渐得到完善。根据现在的诱导神经元的研究进展,对其安全性和有效性进行评估。
Central nervous system injury and neurodegenerative disease needs important source of cell for transplantation treatment. Now, neuron generation research focuses on induced pluripotent stem cells （iPSCs） technology and direct somatic cell reprogramming. At present, there are several ways to induce somatic cell into mature neurons efficiently. From a security point of view, the neuronal generation approach needs to he improved. According to the current research progress of induced neurons, its safety and efficacy were evaluated.
作者
张东明
焦建伟
ZHANG Dong-Ming JIAO Jian-Wei(Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China)
出处
《生命科学》
CSCD
2016年第8期883-887,共5页
Chinese Bulletin of Life Sciences
基金
中国科学院"干细胞与再生医学研究"战略性先导科技专项(XDA01020301)
关键词
神经元
转分化
细胞移植
小分子化合物
neuron
direct reprogramming
cell transplantation
small molecule compound
