摘要
目的研究腹部手术后早期炎性肠梗阻患者采用生长抑素治疗的临床效果及其对血清炎症因子水平的影响。方法临床纳入我院2013年4月～2015年6月期间收治的腹部手术后早期炎性肠梗阻患者120例．将其按床位单双号分为两组各60例。其中对照组采用常规治疗，观察组在上述基础上联合生长抑素治疗。观察两组患者治疗效果、血清炎症因子水平变化情况、症状恢复情况以及不良反应等。结果观察组和对照组治疗总有效率分别为96．67％、83．33％，观察组明显高于对照组，差异具有统计学意义（P〈0．05）。治疗前两组患者hs—CRP、TNF-α水平比较，差异无统计学意义（P〉0．05）；治疗后观察组hs—CRP、TNF-α水平明显低于对照组，差异具有统计学意义（P〈0．05）。观察组患者恶心呕吐消失时间、腹胀腹痛恢复时间、肛门排气时间以及住院时间均短于对照组，差异具有统计学意义（P〈0．05）。两组患者不良反应包括腹腔感染、腹腔积液，观察组和对照组发生率分别为13．33％、36．67％，观察组明显低于对照组，差异具有统计学意义（P〈0．05）。结论生长抑素有助于促进手术患者术后的恢复，在对抗炎性肠梗阻时效果显著，症状恢复快，不良反应少，值得临床应用及推广。
Objective To investigate the clinical effect of somatostatin in treatment of early postoperative inflammatory ileus and its influence on levels of serum inflammatory factors. Methods 120 patients with early postoperative inflammatory ileus treated in our hospital from April 2013 to June 2015 were selected and divided according to bed numbers into two groups, each with 60 cases. The 60 patients who were given routine treatment were considered as control group, while the other 60 who were additionally given somatostatin were considered as observation group. The treatment effects, changes of serum inflammatory factor levels, remission of symptoms, and adverse reactions were observed. Results The overall response rates were 96.67% and 83.3：3% in the observation group and the control group, respectively, which was significantly higher in the observation group （P〈0.05）. Before treatment, there were no significant differences in hs-CRP or TNF-α levels between two groups （P〉0.05）, while after treatment, the levels of hs-CRP or TNF-α were significantly lower in the observation group than in the control group （P〈0.05）. The remission time of nausea and vomit- ing, abdominal distension, and abdominal pain, time to anal exsufflation, and hospital stay were all significantly shorter in the observation group than in the control group（P〈O.05）. Conclusion Somatostatin facilitates the recovery of patients after operation and has significant effect again inflammatory ileus, with short time of remission and low incidence of adverse reactions, which is worthy to be promoted.
出处
《中国现代医生》
2016年第20期26-28,共3页
China Modern Doctor
关键词
生长抑素
肠梗阻
炎症因子
腹部手术
Somatostatin
Ileus
Inflammatory factor
Abdominal operation
