摘要
目的探讨奥曲肽对术后早期炎性肠梗阻患者炎性介质(IL-6,TNF-α)表达的影响。方法将术后早期炎性肠梗阻患者25例随机分为标准治疗组(对照)10例,奥曲肽组15例,比较两组治疗后2,4,6,10 d的IL-6,TNF-α变化情况和胃肠减压量、肠通气时间。结果与对照组比较,奥曲肽组IL-6,TNF-α的表达明显降低(P<0.01),胃肠减压量明显减少,肠通气时间明显缩短(P<0.05)。结论应用奥曲肽治疗炎性肠梗阻患者能有效降低机体炎性介质(IL-6,TNF-α)的表达,有利于肠道功能的恢复,值得推广应用。
Objective To study the effects of tota parenteral nutrition with Somatostatin on the patients with early postoperative inflammatory small intestinal obstruction.Methods Patients treated with Somatostatin were compared with those treated without related medicine（as control）.Inflammatory mediators expression（IL-6 and TNF-α） of patients who have been treated for 2,4,6,10 days by ELISA were detected,followed by the recording of intestinal ventilation and feeding time,cure time.Results Compared with control group,Somatostatin group significantly reduced inflammatory mediators expression level（IL-6 and TNF-α）（P0.01）,the intestinal tract secretion flow and the cure time and bowel ventilation time（P0.01）.Conclusion Somatostatin of parenteral nutrition can obviously increase the effects of early inflammatory bowel obstruction,shorten the curative process and reduce the inflammatory factor expression,so it is worth putting to wide application.
出处
《湖北民族学院学报（医学版）》
2011年第4期36-37,共2页
Journal of Hubei Minzu University(Medical Edition)
关键词
生长抑素
炎症性肠梗阻
炎性介质
Somatostatin
inflammatory intestinal obstruction
inflammatory mediator
