摘要
目的研究奥美拉唑、埃索美拉唑与抗生素联用治疗消化性溃疡的临床疗效及其对炎性因子的影响。方法选择2015年1月至12月在我院接受治疗的Hp阳性的消化性溃疡患者180例,随机分为对照组和实验组,每组各90例,对照组采用奥美拉唑联合阿莫西林和克拉霉素进行治疗,实验组采用埃索美拉唑联合抗生素进行治疗。比较两组患者的炎性因子、GAS水平、胃镜疗效、临床症状得分和Hp根除率。结果治疗前实验组和对照组患者的hs—CRP、IL-8、TNF-α和GAS水平比较,差异无统计学意义(P>0.05),治疗后两组患者的以上指标均明显下降,实验组患者的炎性因子和GAS水平更低(P<0.05)。实验组患者的胃镜痊愈率为82.22%,总有效率为94.44%,明显高于对照组(P<0.05)。治疗前实验组和对照组患者泛酸、嗳气、上腹痛、腹胀等临床症状得分比较,差异无统计学意义(P>0.05),治疗后两组患者的临床症状得分均明显下降,实验组患者的得分更低(P<0.05)。实验组有88例患者Hp根除,根除率为97.78%,对照组有80例患者Hp根除,根除率为88.89%,差异有统计学意义(P<0.05)。结论埃索美拉唑联合抗生素治疗Hp阳性消化性溃疡的临床疗效优于奥美拉唑,对炎性因子和GAS的效果较好,临床症状改善效果好。
Objective To study the effect of omeprazole or esomeprazole combined with antibiotics in treatment of peptic ulcer and influence on inflammatory factors. Methods A total of 180 cases of the Helicobacter pylori （Hp） positive digestive ulcer patients who were treated in our hospital were selected from January to December 2015 were randomly divided into experimental and control groups, each group had 90 cases. The control group was given with omeprazole combined with amoxicillin and clarithromycin; experimental group was treated by esomeprazole combined with antibiotics. Clinical inflammatory factors were also compared between two groups; those included, the level of GAS, gastroscope curative effect and the clinical symptoms score and the eradication rate of Hp. Results hs CRP, IL-8, TNF-a and serum gastrin level had no significant difference before treatment between two groups （P 〉 0.05）, they were significantly decreased after treatment in experimental group. Inflammatory factor and gas levels were also lower in the experimental group （P 〈 0.05）. By examination of Gastroscopy patients in the experimental group had a cure rate of 82.22%, the total effective rate of 94.44%, which were significantly higher than that in the control group （P 〈 0.05）. Clinical symptom score including pantothenic acid, heating, upper abdominal pain, abdominal distension had no significant difference before treatment between two groups （P 〉 0.05）, but the score was significantly decreased after treatment in the experimental group（P 〈 0.05）. The experimental group of 88 patients had Hp eradication, the eradication rate was 97.78%, the control group of 80 patients has Hp eradication, eradication rate was 88.89%, the difference was statistically significant （P 〈 0.05）. Conclusion Esomeprazole combined with antibiotics in the treatment of Hp peptic ulcer had a better curative effect than treated by omeprazole. The combined treatment showed improved inflammatory factors and less gas and clinical symptoms were much improved.
出处
《标记免疫分析与临床》
CAS
2016年第7期779-782,共4页
Labeled Immunoassays and Clinical Medicine
