摘要
目的研究血清及尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平与脓毒症急性肾损伤(AKI)患者肾功能转归的关系。方法选取2012年2月至2015年2月期间收治的82例脓毒症患者作为研究对象,其中AKI患者45例,非AKI患者37例,比较非AKI及AKI不同转归患者的估算肾小球滤过率(e GFR)、血肌酐(Scr)、s NGAL及u NGAL水平。应用ROC曲线分析s NGAL及u NGAL对AKI患者肾功能转归的预测价值。结果非AKI及AKI不同转归患者的Scr、s NGAL、u NGAL及e GFR的差异具有统计学意义(P<0.05)。ROC曲线分析:u NGAL预测肾功能不良的临界值为231.7 ng/ml,曲线下面积为0.895,敏感度为90.9%,特异度为88.2%;s NGAL分别为207.4 ng/ml,0.774,81.8%及91.2%;Scr分别为3.2 mg/dl,0.615,81.8%及85.3%。结论脓毒症并发AKI患者的血清及尿NGAL明显升高,检测NGAL水平对患者肾功能转归具有预测价值。
Objective To study the relativity of serum/ urine neutrophil gelatinase - associated lipocalin（NGAL）and the outcome of pa-tients of sepsis combined with acute kidney injury（AKI）. Methods From February 2012 to February 2015,82 patients with sepsis were chosen as study objects,45 patients were combined with AKI,others 37 patients without AKI. The eGFR,Scr,sNGAL and uNGAL were compared a-mong non - AKI patients and AKI patients with different outcome. The predicting value of sNGAL and uNGAL in the outcome of patients with AKI was analyzed with ROC. Results eGFR,Scr,sNGAL and uNGAL had significant difference among different patients（ P 〈 0. 05）. ROC analy-sis：The threshold of uNGAL was 231. 7 ng/ ml,the area under curve was 0. 895,the sensitivity was 90. 9% ,and the specificity was 88. 2% ;these parameters of sNGAL were 207. 4 ng/ ml,0. 774,81. 8% and 91. 2% ,respectively;these parameters of Scr were respectively 3. 2 mg/ dl, 0. 615,81. 8% and 85. 3% . Conclusion The serum/ urine NGAL increases significantly in patients of sepsis combined with acute kidney injury, which would help to predict the outcome of kidney function.
出处
《临床和实验医学杂志》
2016年第13期1291-1294,共4页
Journal of Clinical and Experimental Medicine
