摘要
目的系统评价美金刚治疗帕金森病（Parkinsun’Sdisease，PD）的安全性和疗效。方法利用计算机检索美国国立医学图书馆、万方数据库、维普中文科技期刊数据库和中国生物医学文献数据库，获得相关参考文献，由两名评价研究人员独立进行筛选研究和质量评价，利用RevMan5．0软件进行荟萃分析。结果共检索相关文献78篇，通过阅读标题及摘要筛选出21篇文献，进一步阅读全文，最终入选12篇文献（共683例PD患者）。荟萃分析显示，美金刚组患者简易智能量表（MMSE）评分与对照组比较差异有统计学意义（SMD=1．91，95％CI：0．53～3．29；P=0．007）；统一帕金森病评分量表（UPDRS）评分与对照组比较差异无统计学意义（SMD=-2．14，95％CI：-6．46～2．19；P=0．33）；蒙特利尔认知评估量表（MoCA）评分与对照组相比，差异有统计学意义（SMD=2．88，95％CI：2．32—3．43；P〈0．01）。日常生活能力量表（ADL）评分基本完成组高于对照组（SMD=2．18，95％CI：1．37～3．47，P=0．0009），部分完成组与对照组之间也具有统计学差异（SMD=0．43，95％CI：0．26—0．72，P=0．001）。结论现有证据表明美金刚对PD患者认知功能、运动症状有改善作用，对改善日常生活能力有一定临床效果，可在一定程度上提高PD患者的生活质量。
Objective To systematically evaluate the efficacy and safety of memantine in the treatment of Parkinson＇ s disease （PD）. Methods Literature about randomized trials of memantine for treatment of PD was retrieved from PubMed, Wanfang Data, VIP and Chinese Biology Medicine （CBM）. Two reviewers independently evaluated the quality of included articles. Then, a meta - analysis was performed using RevMan 5.0 software. Results A total of 78 articles were retrieved, in which 21 articles were screened out. After reading, 12 prospective, randomized controlled clinical tri- als were included （with 683 PD patients totally）. Compared with the control, the memantine group produced significantly different scores of the mini - mental state examination （MMSE） （ SMD = 1.91, 95% CI： 0. 53 - 3.29 ; P = 0. 007） and the Montreal cognitive assessment （MoCA） scale （ SMD = 2.88, 95% CI： 2.32 - 3.43 ; P 〈 0.01 ）. No statistical difference was found in the unified Parkinson＇s disease rating scale （UPDRS） scores between both groups （SMD = -2.14, 95% CI： - 6.46 - 2.19 ; P = 0.33 ）. The scores of activity of daily life （ADL） scale were higher in the basic completion group than those in the control （ SMD = 2.18, 95% CI： 1.37 - 3.47, P = 0. 0009）. Meanwhile, the scores of ADL in the partial completion group were remarkably different from those in the control group （ SMD = 0.43, 95% CI： 0. 26 - 0.72, P = 0.001 ）. Conclusion The current evidence shows that memantine can markedly improve PD patients＇ cogni- tive function and motor symptoms as well as their quality of life.
出处
《徐州医学院学报》
CAS
2016年第5期301-306,共6页
Acta Academiae Medicinae Xuzhou
基金
国家自然科学基金（81301077）
江苏省高校自然科学基金（13KJB320026）
关键词
帕金森病
美金刚
评分
运动症状
荟萃分析
Parkinson＇s disease
memantine
score
motor symptoms
meta- analysis
