摘要
目的：分析持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的疗效及安全性,探讨其临床适用性。方法：选取2013年5月至2015年5月于我院就诊治疗的68例应激性溃疡新生儿,随机分为试验组和对照组各34例,对照组患儿采用奥美拉唑0.8 mg/（kg·d）静脉滴注,试验组患儿采用奥美拉唑2.0 mg/kg持续24 h微泵静脉滴注,观察两组患儿治疗后的临床疗效、平均止血时间和胃内p H的动态变化。结果：试验组总有效率为100%,对照组总有效率为97.06%,两组比较差异无统计学意义（χ2=1.01,P〉0.05）,但试验组患儿的显效率明显高于对照组（χ2=21.11,P〈0.05）。止血时间试验组为（1.04±0.29）d,对照组为（1.98±0.57）d,两组比较差异有统计学意义（t=8.57,P〈0.05）。治疗前两组患儿的胃内p H值比较差异无统计学意义（P〉0.05）,治疗后3~24 h试验组患儿的胃内p H明显高于对照组（P〈0.05）。两组患儿治疗期间均未出现药物相关不良反应。结论：持续小剂量微泵滴注奥美拉唑治疗新生儿应激性溃疡的疗效显著,可以有效改善患儿的不适症状,尽快止血,稳定调节胃内p H,且安全有效,适合临床长期推广应用。
Objective： To analyze the efficacy and safety of continuous low dose infusion of micro pump with omeprazole in the treatment of neonatal stress ulcer. Methods： Sixty eight cases of stress ulcer in children were selected in Yan＇an University Affiliated Hospital from May 2013 to May 2015. All children were randomly divided into the experimental group（ 34 cases） and the control group（ 34 cases）. The control group was treated with omeprazole 0. 8 mg/（ kg·d） for intravenous drip,while the experimental group was treated with omeprazole 2. 0 mg / kg continuous low-dose intravenous drip with micro pump. The clinical effect of two groups after treatment,the average hemostatic time and the dynamic changes of p H in the stomach were observed. Results： The total effective rate was 100% in the experimental group and 97. 06% in the control group,and the difference was not statistically significant（ χ2= 1. 01,P0. 05）,but the effective rate in the experimental group was significantly higher than that in the control group（ χ2= 21. 11,P 0. 05）.The average hemostatic time of the experimental group was（ 1. 04±0. 29） d,the average hemostatic time of the control group was（ 1. 98±0. 57） d,and the difference was statistically significant（ t = 8. 570,P0. 05）. There was no significant difference in p H values between the two groups before treatment（ P0. 05）,and the change of p H in 3 to 24 h after treatment in the experimental group was significantly better than that of the control group（ P 0. 05）. No drug related adverse reactions occurred during the treatment of the two groups.Conclusion： The efficacy of continuous low dose infusion of micro pump with omeprazole in the treatment of neonatal stress ulcer is significant,and it can effectively improve the symptoms of children,stop bleeding,and stabilize the gastric p H,and it is safe and effective.
出处
《儿科药学杂志》
CAS
2016年第6期19-21,共3页
Journal of Pediatric Pharmacy
