摘要
目的:观察持续小剂量静脉滴注奥美拉唑治疗新生儿应激性溃疡的疗效。方法:2011年至2012年在重庆三峡中心医院儿童分院诊断为新生儿应激性溃疡的患儿72例,随机分为治疗组36例和对照组36例。在综合治疗的基础上,对照组用奥美拉唑0.8 mg/(kg.d)静脉滴注,每天1次,连用3d,治疗组予奥美拉唑2 mg/kg持续小剂量静脉滴注24 h。结果:两组止血效果比较,显效率治疗组为94.44%,高于对照组的44.4%,治疗组和对照组平均所需止血时间分别为(1.05±0.05)d和(2.08±0.96)d,两组比较差异均有统计学意义(P<0.05)。治疗组胃液pH由用药前的(2.19±0.06)上升为用药后4 h的(5.08±0.22);用药后呼吸、心率、血压无明显变化;用药前后的白细胞、血小板计数和肝脏酶学检查比较差异均无统计学意义,亦未见增加其他药物的毒副作用。结论:持续小剂量静脉滴注奥美拉唑是治疗新生儿应激性溃疡高效、安全的措施,值得临床推广应用。
Objective： To observe the efficacy of continuous intravenous infusion of low-dose omeprazole in the treatment of neonatal stress ulcer.Methods： From 2011 to 2012,72 cases of neonatal stress ulcer were diagnosed in our hospital.They were randomly divided into an experimental group and a control group equally.The experimental group received continuous infusion of low-dose omeprazole 2 mg/kg for 24 hours,on the basis of comprehensive treatment.The control group received omeprazole 0.8 mg/（kg·d） intravenous infusion,one time per day,for three days.Results： The apparent efficiency in hemostatic effect in the experimental group was 94.44%,which was higher than that 44.4% of the control group.The average time to stop bleeding in the experimental group and the control group were（1.05±0.05） d and（2.08±0.96） d.The difference was statistically significant.The gastric juice pH in the experimental group before treatment was（2.19 ± 0.06）,then was risen to（5.08±0.22）-（5.59±0.42） and remained.After treatment,breathing,heart rates,and blood pressure had no significant change.There was not statistically different in white blood cell and platelet counts and liver enzymes values before and after treatment.No side effects of other application drugs were found.Conclusions： Continuous low-dose intravenous omeprazole treatment of neonatal stress ulcer is efficient,safe and worthy of clinical application.
出处
《儿科药学杂志》
CAS
2013年第1期12-14,共3页
Journal of Pediatric Pharmacy
