摘要
目的分析维生素D3治疗对并发糖尿病老年牙周炎患者辅助性T细胞及相关细胞因子的影响。方法选取80例牙周炎老年患者随机分为对照组及观察组,对照组患者行牙周基础疗法,观察组患者在对照组基础上额外使用维生素D3进行干预,对患者的临床有效率、Th1及Th2细胞数、TNF-α、IL-6、IL-4、IFN-γ、Ig M、Ig A、Ig G水平进行记录分析。结果经VD3干预后患者IL-4及IL-10水平均显著降低(P<0.05),且观察组患者IL-4及IL-10水平显著高于对照组(P<0.05);经VD3干预后患者IFN-γ及TNF-α水平均显著降低(P<0.05),且观察组患者IFN-γ及TNF-α水平显著低于对照组(P<0.05);观察组患者Ig M、Ig A及Ig G水平均明显高于对照组(P<0.05);观察组患者Th1细胞显著低于对照组(P<0.05),但Th2细胞显著高于对照组(P<0.05),观察组患者Th1/Th2比显著低于对照组(P<0.05)。结论在对老年病合并牙周炎患者进行治疗时额外使用VD3进行辅助治疗,可以多向调节患者免疫功能,并有效提高Th1/Th2细胞比例及生理功能的同时促进免疫球蛋白的分泌。
Objective To analyse influence of vitamin D3 on helper T cells and the correlative cytokines in treatment of elderly patients with periodontitis complicated with diabetes. Methods 80 elderly patients with periodontitis complicated with diabetes were divided into control group and observation group,control group patients were given periodontal basic treatment,observation group of patients in the control group on the basis of additional intervention using vitamin D3,the clinical efficient and Th1 and Th2 cells number,TNF-α,IL-6,IL-4,IFN-γ,Ig M and Ig A,Ig G level were recorded. Results After VD3 intervention,IL-4 and IL-10 levels of patients were significantly lower（ P〈0. 05）,and IL-4 and IL-10 in the observation group were significantly higher than that of control group（ P〈0. 05）; After VD3 intervention,IFN-γ and TNF-α level were significantly lower（ P〈0. 05）,and IFN-γ and TNF-α level in the observation group were significantly lower than control group（ P〈0. 05）; Ig M and Ig A and Ig G levels in observation group were significantly higher than that of control group（ P〈0. 05）; Th1 cells in the observation group was significantly lower than control group（ P〈0. 05）,but the Th2 cells was significantly higher than that of control group（ P〈0. 05）,Th1 / Th2 ratio in the observation group was significantly lower than control group（ P〈0. 05）. Conclusion Vitamin D3 in treatment of elderly patients with periodontitis complicated with diabetes can adjust the immune function in patients with multi-directional,and improve the proportion of Th1 / Th2 cells and physiological functions,at the same time promote the secretion of immunoglobulin.
出处
《中国生化药物杂志》
CAS
2016年第3期52-54,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
维生素D3
并发糖尿病老年牙周炎
辅助性T细胞
细胞因子
Vitamin D3
Complicated with diabetes mellitus elderly periodontitis
Helper T cells
cytokines
