摘要
目的 观察牙周非手术治疗对2型糖尿病伴慢性牙周炎（chronic periodontitis,CP）患者牙周状况、糖代谢及血清白细胞介素6（IL-6）的影响,探讨其可能的影响机制.方法 选取2型糖尿病伴慢性牙周炎（type 2 diabetes mellitus with chronic periodontitis,DMCP组）和不伴有全身系统性疾病的CP患者（CP组）各55例进行牙周非手术治疗,其中DMCP组中糖化血红蛋白（glycated hemoglobin,HbA1c）＜7.00%的患者为血糖控制较好组（A1组）,HbAlc≥7.00%的为血糖控制较差组（A2组）.在治疗前及治疗后6周、3个月时分别记录全口探诊深度（probing depth,PD）、附着丧失（attachment loss,AL）、出血指数（beeding index,BI）和菌斑指数（plaque index,PLI）,并检测空腹血糖（fasting plasma glucose,FPG）、HbA1c及血清IL-6水平.结果 DMCP组和CP组PD、AL、BI、PLI和血清IL-6水平在治疗后6周及3个月时均显著降低（P＜0.05）,其中DMCP组血清IL-6从（3.47±0.33）ng/L（治疗前）显著降至（3.21±0.66）ng/L（治疗后6周）,再降至（3.03±0.54）ng/L（治疗后3个月）.DMCP组治疗后3个月HbA1c水平[（6.80±1.21）%]与治疗前[（7.35±1.73）%]相比显著降低（P＜0.05）,其中A2组HbA1c水平从治疗前的（8.72±1.51）%显著降至治疗后3个月的（7.59±1.28）%（P＜0.05）,而A1组HbA1c水平则无明显变化（P＞0.05）.结论 牙周非手术治疗能够降低DMCP患者血清IL-6水平,并在一定程度上改善患者糖代谢状况 该治疗能显著改善血糖控制较差者的糖代谢,而对血糖控制较好者的糖代谢则无明显影响.
Objective To evaluate the effect of non-surgical periodontal therapy on periodontal status, glycemic control and the level of serum interleukin（IL）-6 in type 2 diabetic patients with chronic periodontitis （DMCP）. Methods Fifty-five DMCP and 55 systemically healthy patients with chronic periodontitis（CP） were recruited in this study. The diabetes were classified into two groups, the wellcontrolled group [glycated hemoglobin （HbA1c） 〈 7.00%]and the poorly controlled group （HbA1c ≥7.00%）. All subjects received non-surgical periodontal therapy. Periodontal clinical parameters including periodontal probing depth （PD）, attachment loss （AL）, bleeding index （BI） and plaque index （PLI） were recorded at baseline, 6 weeks and 3 months after the treatment. Fasting plasma glucose（FPG）, HbA1c and the concentration of serum IL-6 were measured. Results At 6 weeks and 3 months after treatment, PD,AL, BI, PLI and the concentration of serum IL-6 of both groups significantly reduced（P 〈 0. 05）. The level of IL-6 in diabetic patients reduced significantly from （3.47 ±0.33） ng/L to （3.21 ±0.66） ng/L and to （3.03 ± 0. 54） ng/L. The HbA1c of diabetic patients reduced significantly 3 months after treatment [（6.80±1.21%]compared with the baseline[（7.35 ± 1.73）%, P 〈0.05]. HbA1c of the poorly controlled group reduced significantly（P 〈0. 05）, while HbA1c of the well-controlled diabetes did not show any apparent reduction （P 〉 0. 05）. Conclusions Non-surgical periodontal therapy can effectively reduce the concentration of serum IL-6, thereby improving glycemic control in type 2 diabetes patients with chronic periodontitis. However, there was no any significant reduction of HbA1c in the well-controlled diabetes.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2011年第2期70-74,共5页
Chinese Journal of Stomatology
基金
基金项目：“十一五”国家科技支撑计划（2007BAl18B02）
辽宁省科技计划（2007225007）
关键词
牙周炎
糖尿病
2型
白细胞介素6
血红蛋白A
糖基化
Periodontitis Diabetes mellitus, type 2 Interleukin-6 Hemoglobin A,glycosylated
