摘要
Caspase-3和Caspase-8作为含半胱氨酸的天冬氨酸蛋白水解酶家族成员,是参与细胞凋亡过程的两个重要蛋白。Caspase-8是重要的凋亡启动蛋白,可通过多种途径介导凋亡反应的发生,Caspase-3作为凋亡过程中的执行者,活化后可以加速细胞凋亡的发生。最新研究发现Caspase-3和Caspase-8在扁平苔藓皮损处(特别是基底层处)高表达,表明两者可能参与了扁平苔藓的凋亡过程,并导致了本病的病理变化。
Caspase- 3 and Caspase- 8 are important proteins in the process of apoptosis. Caspase- 8 can start apoptotic reaction which can mediate apoptosis in a variety of ways. Caspase- 3 can accelerate cell apoptosis after activation. The new studies reported high expression of Caspase- 3,Caspase- 8 in lichen planus lesions,especially in the basal layer which showed that Caspase- 3,Caspase- 8 might be involved in the apoptotic response process of lichen planus.
出处
《中国麻风皮肤病杂志》
2016年第4期254-256,共3页
China Journal of Leprosy and Skin Diseases
