摘要
目的探讨胃癌组织中核黄素转运蛋白2(riboflavin transporter-2,RFT2)表达及其与胃癌临床病理参数之间的关系。方法取胃癌石蜡包埋组织标本及癌旁胃黏膜组织标本各60例,用免疫组织化学方法检测癌组织RFT2蛋白表达水平。结果 RFT2蛋白在胃癌组织中的表达水平低于癌旁正常胃黏膜组织(P<0.05)。胃癌组织中RFT2蛋白表达水平在胃癌的分化程度、TNM分期、Lauren组织学分型方面差异有统计学意义(均P<0.05),在患者性别、民族、年龄、有无淋巴结转移、肿瘤大小方面差异无统计学意义(均P>0.05)。结论 RFT2蛋白表达在人胃癌组织中表达显著下降,其表达与肿瘤组织分化程度及TNM分期密切相关。
Objective To investigate the expression of riboflavin transporter-2（ RFT2） in gastric cancer and its clinicopathological significance. Methods Sixty paraffin-embedded,formalin-fixed gastric cancer samples and 60 tumoradjacent stomach mucous tissues were collected. Immunohistochemical staining was employed to detect the expression level of RFT2 in the tissues. Results The expression of RFT2 was significantly lower in gastric cancer tissue than that in adjacent normal tissue（ P〈0. 05）. The expression of RFT2 was significantly different in cases with different differentiation degree,TNM stage and Lauren histologic type（ P〈0. 05）,but not significantly different in cases with different gender,ethnicity,age,lymph node metastasis or tumor size（ P〉0. 05）. Conclusion The expression of RFT2 is down-regulated in gastric cancer tissue,and it is correlated with both histological differentiation degree and TNM stage of the tumor.
出处
《实用肿瘤杂志》
CAS
2016年第2期154-157,共4页
Journal of Practical Oncology
