摘要
目的分析雾化吸入阿米卡星治疗重症肺炎的疗效及安全性,探讨其临床应用价值。方法选择就诊的60例重症肺炎患者,按简单数字表法随机分为试验组和对照组各30例,对照组患者先予头孢哌酮舒巴坦钠静脉滴入,后经药敏结果可更换敏感抗生素,同时给予0.9%氯化钠5ml雾化吸入;试验组患者抗生素静脉给药同对照组,同时给予阿米卡星400mg雾化吸入。观察两组患者临床治愈率、细菌清除率、治疗前后肺功能、血气分析指标变化和治疗过程中的不良结局情况。结果试验组患者临床治愈27例(90.00%),对照组患者临床治愈20例(66.67%),两组患者临床治愈率比较差异有统计学意义(2=4.8118,P=0.0283);试验组患者细菌完全清除24例(80.00%),对照组患者细菌完全清除16例(53.33%),两组患者细菌清除率比较差异有统计学意义(2=4.8000,P=0.0285)。治疗前两组患者肺功能指标无明显差异(P>0.05),治疗后肺功能指标,试验组患者改善程度明显优于对照组,差异有统计学意义(P<0.05)。结论雾化吸入阿米卡星治疗重症肺炎疗效可靠,可有效改善患者的肺功能和动脉血气,安全性好,适合临床长期推广应用。
Objective To analyze the efficacy and safety of aerosolized amikacin on the treatment of severe pneumo- nia and explore its clinical applicability. Methods 48 patients with severe pneumonia were selected from October 2013 to May 2015 in our hospital, and they were randomly divided into the experimental group （24 cases） and the control group （24 cases）. The control group was treated with cefoperazone sulbactam intravenous inhalation of 5ml saline 0.9 %. After susceptibility results the drug replace with sensitive antibiotic. The experimental group was treated with antibiotics and inhalation os 400mg amikacin. The clinical cure rate, bacterial clearance, lung function and blood gas analysis and the ad- verse reactions were observed. Results There were 27 cases （90.00%） and 20 cases （66.67%） cured in the experimen- tal group and control group. The clinical cure rate of the two groups was statistically significant （X2 = 4. 118, P = 0. 0283）. The completely bacterial clearance rate of the experimental group and control group were 80.00 % （24/30）and 53.33% （16/30） （X2 =4. 8000,P=0. 0285）. The lung function before treatment of the two groups showed no significant difference （P〉0.05）. The pulmonary function were improved after treatment （P〈0.05）. The degree of improvement of the experimental group were significantly better than that of the control group （P〈0.05）. Conclusions Aerosolized a.mi- kacin in the treatment of severe pneumonia is reliable, which can improve lung function and arterial blood gas.
出处
《西部医学》
2016年第1期77-79,83,共4页
Medical Journal of West China
基金
四川省卫生厅科研课题(120545)
