摘要
目的:探讨绝经后心肌梗死（MI）患者性激素（SH）与脂代谢之间的关系。方法:利用放免法、免疫酶法、酶法分别检测绝经后妇女MI组（30例）和绝经后妇女对照组（30例）血中雌二醇（E2）、孕酮（P）、睾酮（T）、脂蛋白（a）[Lp（a）]、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平。结果:与绝经后妇女对照组相比,绝经后MI组E2、E2/P、E2/T、HDL-C水平显著降低（100.35±41.26pmol/L:148.38±46.44pmol/L,P<0.001,90.52±65·48:149.75±116.74,P<0.05,104.52±64.24:154.22±111.34,P<0.05,0.95±0.30mmol/L:1.12±0.43mmol/L,P<0.05）,Lp（a）、LDL-C、TG、TC水平明显升高（21.31±17.93 mg/dl:13.52±13.04mg/dl,P<0.05.2.98±1.04mmol/L:2.15±1.19mmol/L,P<0.05,1.63±1.44mmol/L:1.13±0.55mmol/L,P<0.05,4.23±0.94mmol/L:3.50±1.36mmol/L,P<0.05）,E2与Lp（a）、LDL-C均呈负相关（r=-0.373,P<0.05,r=-0.635,P<0.01）,与HDL-C呈正相关（r=0.378,P<0.05）.结论:绝经后MI患者存在明显的以E2。水平不足为主的性激素紊乱和脂代谢异常,脂代谢异常和E2水平不足密切相关;E2水平不足促进脂代谢异常,可能是绝经后妇女MI发生的重要原因之一。
The purpose of this study is to find the relationship between sex hormone (SH) and lipid metabolism in postmenopausal women with myocardial infarction (MI) Methods: Using the technique of radioimmunoassay. ELISA and enzymatic method, we determined the blood level of E2-17β (E2), progesterone (P), testosterone (T), Lp (a), TG, TC, HDL-C, LDL-C of 30 postmenopausal women with MI and 30 healthy postmenopausal women. Results: The blood level of E2, E2/P, E2/T, HDL-C of postmenopausal women with MI was significantly decreased compared with control group (100. 35±41. 26pmol/L vs 148. 38±46. 44pmol/L, P<0. 001, 90. 52±65. 48 vs 149. 75±116. 74, P<0. 05, 104. 52±64. 24 vs 154. 22±111. 34, P<0. 05, 0. 95±0.30mmol/L vs 1. 12±0. 43mmol/L, P<0. 05) . The level of Lp (a)、LDL-C、TG、TC was obviously increased compared with control group (21. 31±17. 93 mg/dl vs 13. 52±13. 04mg/dl, P<0. 05, 2. 98±1. 04mmol/L vs 2. 15±1. 19mmol/L, P<0. 05. 1. 63±1.44mmol/L vs 1. 13±0. 55mmol/L, P<0. 05, 4.23±0. 94mmol/L vs 3.50±1. 36mmol/L, P<0. 05). There was negative relation among Es and Lp (a)、LDL-C (r=-0. 373, P<0.05 r=-0. 635, P<0. 01); there was positive relation between E2 and HDL-C (r=0. 378, P<0. 05). Conclusion: There are obviously SH disorder (mainly deficiency of E2 and lipid metabolism disorder in postmenopausal women with MI. Lipid metabolism disorder was closely related to E2 level. It might be one of the important reasons caused the postmenopausal MI.
出处
《心血管康复医学杂志》
CAS
2002年第4期300-303,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
