摘要
作者用99％、75％和60％三种浓度的乙醇分别作犬的肝动脉注射,通过血管造影和病理检查,观察了它们不同的栓塞效果和肝组织反应,结果99％乙醇导致了严重的肝坏死;60％乙醇未能达到确实可靠的血管栓塞,75％乙醇栓塞作用尚好而肝组织损害较轻。作者探讨了乙醇的致栓机理,并讨论了乙醇肝动脉栓塞术用于临床治疗的可行性。
In this experiment, 27 dogs underwenthepatic arterial embolization (HAE) with99% ethanol in 10 (group A) , 75% ethanolin 10 (group B) and 60% ethanol in 7 (groupC) . By the laparotomy, catheter was inser-ted into hepatic artery and ethanol at doseof 0.3 ml/kg was injected within 20 sec-onds. Arterial angiography was taken beforeand after HAE. The dogs were sacrificed in1, 2, 4, 8 weeks. Liver specimens wereexamined grossly and microscopically. Both A and B group showed satisfactory.results of embolization, but 99% ethanolcaused severe damage to hepatocytes,perisinusoidal area and bile duels. Eight of10 dogs died of hepatic failure and infectionwithin two weeks. 75% ethanol mainly oc-cluded the smaller arterial branches. Hepato-cellular and biliary tract lesions were slightand reversible. All the animals survivednormally except two. Group C had somemild and limited liver damage and scatter-ing thrombosis which might result fromintima lesion. This article also discusses the clinical availability of ethanol HAE.
出处
《华西医科大学学报》
CAS
CSCD
1989年第1期42-45,共4页
Journal of West China University of Medical Sciences
关键词
乙醇
栓塞
肝癌
肝动脉
Ethanol
Embolization
Hepatic arteria
Cancer of the liver
