摘要
以四氯化碳诱发的急性肝损伤小鼠为模型。实验前后均喂服硝苯地平。结果显示:小鼠急性肝损伤24小时后,ALT与AST升值减小,一周内降到正常,肝组织损害减轻,一周内基本修复,与对照组比较有显著差异。因此认为硝苯地平对急性肝损伤小鼠有保护作用。
Liver damage in mice was induced by an inorganic chemical CCl4. Nifedipine was given before and after the intoxication. After 24 hours,the increments of ALT and AST in serum of mice with acute liver damage were lower than those of controls. After a week, values of ALT and AST recovered normal. Pathological changes of liver were mild and recovered within a week. It suggested that nifedipine was a protector for mice with acute liver damage.
出处
《天津医药》
CAS
1995年第2期91-92,共2页
Tianjin Medical Journal
