摘要
研究了37例IgG亚类缺陷病患儿淋巴细胞功能,结果表明PWM诱导的体外IgG亚类产生障碍的频度沿IgCH基因5′—3′逐渐增高;IgG_2(7/9)和IgG_4(6/11)较IgG_3(2/13)和IgG_1(9/17)更易受累。除B细胞增殖功能异常外,患儿尚伴有外周血CD_4细胞数量减少、T细胞增殖反应下降、BCDF_(?)和IL-6活性降低。本文指出IgG亚类缺陷病存在沿IgCH基因5′—3′的转换障碍,涉及B细胞、T细胞及其淋巴因子多元性异常。
Measurement of IgG subclass productions, activities of interleukin-6 (IL-6) and B cell differentia- tion faotors (BCDFs) in vitro were carried out on 37 children with IgG subclass deficiency. The frequency of defective IgG subclass productions induced by PWM is in order asfollows: IgG (7/9), IgG4 (6/11), IgGl (9/17) and IgG3 (2/13). Decreased CD4 oells from PBL, low leves of lymphocyte proliferative responses to PHA and SAC, and reduced activities of IL-6 and BCDFs were found in IgG subclass deficiency patinets. 12 out of 15 cases who had decreased IgG subclass production associated with a reduced activities of IL-6 or/and BCDFs; only 4 out of 15 cases who had normal amounts of IgG subclass production associated with such lymphokine defects. The results would suggest that IgG subclass deficiency may be related to the aberration of isotype switch in order along Ig heavy chain constant gene from 5' -3', and that a variety of abnormalities in T and B cell functions share the contribution to the pathogenesis of IgG subclass deficiency, in which T cell dysfunction may play a more important role.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1991年第6期368-371,共4页
Chinese Journal of Immunology
关键词
免疫缺陷病
白细胞介素6
免疫学
Immunoglobulin G subclasses
Immunodeficiency
Interleukin-6
B cell differentiaion factors
