摘要
目的探讨和肽素(copeptin)和心肌肌钙蛋白I(cTnI)、高敏心肌肌钙蛋白T(hs-TnT)联合检测时对急性心肌梗死(AMI)的诊断价值。方法 AMI患者152例(AMI组),同期健康体检者143例(对照组)。(1)考察2组0、4、6及12 h copeptin、cTnI及hs-TnT水平差异。(2)对2组行copeptin与cTnI联合检测(cop/cTnI)、copeptin与hs-TnT联合检测(cop/hs-TnT)。考察AMI组发病后不同时间点上述不同检测指标阳性检出率情况。(3)判断发病即刻各种心肌标志物对AMI诊断的敏感度、特异度及准确度。结果 (1)2组copeptin在发病0、4、6和12 h时差异有统计学意义(P<0.05)。2组cTnI与hs-TnT在0 h时差异无统计学意义。(2)cop/cTnI和cop/hs-TnT联合检测组在不同发病时刻较各自单独检测均具有更高的阳性检出率。(3)cop/cTnI和cop/hs-TnT联合检测的敏感度、特异度以及准确度均高于其单独检测。cop/hs-TnT联合检测最佳。结论 cop/cTnI和cop/hs-TnT联合检测在AMI发病早期即具有较高的敏感度、特异度和准确度,在临床疾病诊断中具有很好的应用价值。
Objective To investigate the diagnostic value of combined copeptin, cardiac troponin I （cTnI） and high sensitive cardiac troponin T （hs-TnT） in determination of acute myocardial infarction （AMI）. Methods A total of 152 patients with AMI were selected as AMI group and 143 healthy examinees during the same period were selected as control group. （1） The levels of copeptin, cTnI and hs-TnT were detected at 0, 4, 6 and 12 h in two groups. （2） The combined detection of cop/ cTnI and cop/hs-TnT were studied. The positive rates of these items were evaluated at different time points of AMI. （3） The diagnostic sensitivity, specificity and accuracy of different cardiac biomarkers for AMI were compared. Results （1） There were significant differences in copeptin at 0, 4, 6 and 12 h between two groups （P 〈 0.05）. There were no significant differences in cTnI and hs-TnT between two groups. （2） cop/cTnI and cop/hs-TnT combined detection showed better positive rates than those of copeptin, cTnI or hs-TnT detection alone. （3） In addition, the combined detection of eop/cTnI and cop/cTnI improved significantly the diagnostic sensitivity of AMI. Compared to cop/cTnI combination, cop/hs-TnT combination detection showed better diagnostic sensitivity, specificity and accuracy for AMI. Conclusion The combined detection of cop/cTnI and eop/hs-TnT are very helpful for early diagnosis of AMI, which shows a very good diagnostic value in clinical application.
出处
《天津医药》
CAS
2015年第11期1319-1322,共4页
Tianjin Medical Journal
关键词
心肌梗死
急性病
早期诊断
敏感性与特异性
和肽素
心肌肌钙蛋白I
高敏肌钙蛋白T
myocardial infarction
acute disease
early diagnosis
sensitivity and specificity
copeptin
cardiac troponin I
high sensitive cardiac troponin T
