血浆和肽素、B型利钠肽水平与慢性心力衰竭的关系被引量：62

The relationship between plasma Copeptin,B type Natriuretic Peptide levels and chronic heart failure

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摘要目的:研究血浆和肽素(copeptin)、B型利钠肽(BNP)水平与慢性心力衰竭(CHF)及其严重程度之间的关系。方法:选择CHF患者78例,入院后均经心脏超声检查,32例非CHF患者作为对照组。按NA分级,将78例CHF患者分为NYHAI-Ⅱ级组30例,Ⅲ级组25例,Ⅳ级组23例。使用放射免疫测定法测定血浆copeptin水平,使用美国Biosite公司产品Triage干式快速定量心肌梗死/心力衰竭诊断检测仪来测定血浆BNP水平。结果:CHF患者血浆copeptin、BNP水平与对照组相比明显升高(P<0.01),并随NA分级的增加而升高。copeptin分别与左室舒张末期内径(LVEDD)值、肌酐、NA分级、BNP呈显著正相关(P<0.01),与左室射血分数(LVEF)呈负相关(P<0.01)。结论:血浆copeptin和BNP水平在CHF中明显升高,copeptin和BNP水平对CHF患者的诊断、病情评估、危险分层具有一定临床意义。 Objective：To investigate the relationship between plasma Copeptin,B type Natriuretic peptide（BNP） levels and the severity of chronic heart failure（CHF）.Method：Seventy-eight patients with CHF were examined by UCG after admission,and 32 patients（no history of heart failure） were chosen as control.CHF patients were divided into three groups according to NYHA＇S heart function class criterion： NYHA class Ⅰand Ⅱ group（30 cases）,Ⅲ group（25 cases） and class Ⅳ group（23 cases）.Copeptin was measured by immune nephelometry,and the concentration of BNP was detected by Triage detection instrument.Result：The levels of plasma Copeptin and BNP in group CHF were significantly higher than those in the controls（P0.01）,and which were elevated with the increase of the New York Heart Association Class.The concentration of Copeptin had a parallel relationship with LVEDD,Cr,NYHA＇S heart function class,BNP（P0.01）,and a negative correlation with left ventricular ejection fraction（LVEF）（P0.01）.Conclusion：Plasma levels of copeptin and BNP are higher in CHF,and the assessment of Copeptin and BNP levels may bring more instructive information in diagnosis,prognostic value,and risk stratification of CHF.

作者李晓涛夏岳郭喜朝魏立业戚国庆

机构地区北京武警总队医院老年病科河北医科大学附属第一医院心内科

出处《临床心血管病杂志》 CAS CSCD 北大核心 2011年第4期268-270,共3页 Journal of Clinical Cardiology

关键词心力衰竭和肽素 B型利钠肽 heart failure Copeptin B-type Natiuretic Peptide

分类号 R541.6 [医药卫生—心血管疾病]

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1MORGENTHALER N G,STRUCK J,ALONSO C,et al.Assay for the measurement of copeptin,a stable peptide derived from the precursor of vasopressin[J].Clin Chem,2006,52:112-119.
2WHITE H D,NORRIS R M,BROWN M A,et al.Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction[J].Circulation,1987,76:44-51.
3STOISER B,M(E)RTL D,H(U)LSMANN M,et al.Copeptin,a fragment of the vasopressin precursor,as a novel predictor of outcome in heart failure[J].Eur J Clin Invest,2006,36:771-778.
4GEGENHUBER A,STRUCK J,DIEPLINGER B,et al.Comparative evaluation of B-type natriuretic peptide,mid-regional proA-type natriuretic peptide,mid-regional pro-adrenomedullin,and Copeptin to predict 12 year mortality in patients with acute destabilized heart failure[J].J Card Fail,2007,13:42-49.
5NEUHOLD S,HUELSMANN M,STRUNK G,et al.Comparison of copeptin,B-type natriuretic peptide,and amino-terminal pro-B-type natriuretic peptide in patients with chronic heart failure:prediction of death at different stages of the disease[J].J Am Coll Cardiol,2008,52:266-272.
6MAISEL A S,KRISHNASWAMY P,NOWAK R M,et al.Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of hear failure[J].New Engl Med,2002,347:161-167.