摘要
目的探讨丙戊酸钠、托吡酯对学龄期癫痫患儿认知功能的影响。方法选择58例癫痫患儿为研究对象(癫痫组)。将58例患儿随机分为两组。A组:30例患儿,给予口服丙戊酸钠治疗。B组:28例患儿,给予口服托吡酯治疗。另选择同期在该院健康体检且结果正常的儿童36例作为对照组。评估治疗前后A组和B组患儿认知功能。结果癫痫组言语智商、操作智商、总智商评分低于对照组(P<0.05)。A组患儿治疗前后言语智商、操作智商、总智商评分比较差异无统计学意义(P>0.05)。B组患儿治疗前后操作智商评分比较差异无统计学差异(P>0.05),但治疗后言语智商、总智商评分低于治疗前(P<0.05)。结论与托吡酯相比较,丙戊酸钠治疗学龄期儿童癫痫时对患儿认知功能影响更小,安全性更高。
Objective To study the effect of sodium valproate ,topiramate on cognitive function of epileptic children of school age .Methods 58 cases of children with epilepsy were recruited in the study（epilepsy group） .58 patients were randomly divided in‐to two groups .Group A ：30 cases ,treated with oral administration of sodium valproate .Group B：28 cases ,treated with topiramate . 36 cases of healthy children who underwent health examination during the same period in the hospital were recruited as control group .Cognitive function were assessed before and after treatment for children in epilepsy .Results VIQ ,PIQ ,FIQ of epilepsy group were lower than the control group（P〈0 .05） .The VIQ ,PIQ ,FIQ of Group A did′t change significantly after treatment（P〉0 .05） .The PIQ of Group B didn′t change significantly after treatment（P〉0 .05） ,while VIQ and FIQ were lower after treatment than before treatment（P〈0 .05） .Conclusion The side effect of sodium valproate is smaller on cognitive function of epileptic chil‐dren of school age and it is safer compared with topiramate .
出处
《国际检验医学杂志》
CAS
2015年第20期2956-2957,2960,共3页
International Journal of Laboratory Medicine
基金
佛山市科技局2012年度计划资助项目(FK2012071)
关键词
癫痫
丙戊酸钠
托吡酯
认知功能
epilepsy
sodium valproate
topiramate
cognitive function
