摘要
探索了微波辐射下酸性功能化离子液体1-(3-磺酸基)丙基-3-甲基三乙胺硫酸盐在Biginelli反应中的催化性。通过正交实验的方法,考察了微波功率、反应时间、物料比、催化剂用量对产率的影响,合成了一系列3,4-二氢嘧啶-2-酮,产率为88.0%-96.1%。与传统方法相比,该合成法操作简单、反应时间短、产率高。
The Acidic functionalized ionic liquid 1-（3-sulfonic Acid） Propyl Triethylamine Sulfate was prepared and used to catalyze the Biginclli reaction by microwave method. The influences of other conditions including the microwave power, reaction time, amount of ionic liquid and material ratio on the yields were investigated by orthogonal test, and a series of 3,4-dihydropyfimidine-2-（ 1H）-ones were synthesized. The yields were 88.0% - 96.1%. Comparing with conv- entional methods, this method has such advantages as simple procedure, short reaction time and high yield.
出处
《廊坊师范学院学报（自然科学版）》
2015年第5期59-61,68,共4页
Journal of Langfang Normal University(Natural Science Edition)
基金
廊坊师范学院科研基金资助项目(LSZY201301)
河北省大学生创新创业训练计划项目(201410100008)
