摘要
目的：探讨重度子痫前期单双胎妊娠发生不良结局的高危因素,为围生保健提供重要临床资料。方法：纳入2005年至2014年四川大学华西第二医院的重度子痫前期住院患者1856例,采用多因素Logistic回归分析单双胎妊娠孕妇发生不良结局的高危因素。结果：双胎妊娠发生不良结局的比例（62.1%）高于单胎妊娠（50.7%）,差异有统计学意义（OR1.592,95%CI 1.228~2.062,P〈0.001）。Logistic回归分析显示,单胎妊娠有统计学意义的高危因素包括：发病孕周〈34周和34~37周、高龄（≥35岁）、孕前BMI 25~30kg/m2、未产检、IVF、合并ICP、合并GDM、合并肾脏疾病（P〈0.05）;双胎妊娠中有统计学意义的高危因素包括：发病孕周〈34周、IVF、合并ICP（P〈0.05）。结论：重度子痫前期双胎妊娠发生不良结局的风险高于单胎妊娠。在单胎妊娠中,发病孕周在37周前、高龄（≥35岁）、孕前BMI 25~30kg/m2、未产检、IVF、合并症（ICP、GDM、肾脏疾病）的患者发生不良结局的风险更高;在双胎妊娠中,发病孕周〈34周、IVF、合并ICP的患者发生不良结局的风险更高。
Objective：To explore the risk factors for adverse outcomes of severe preeclampsia in singleton and twin pregnancies,providing important clinical data for perinatal care.Methods：The clinical data of 1856 cases of singleton and twin pregnancies at West China Second Hospital,Sichuan University from 2005 to 2014were retrospectively analyzed.The risk factors for adverse outcomes of severe preeclampsia were analyzed with multivariate Logistic regression analysis.Results：The risk of adverse outcomes in twin pregnancies（62.1%）was significantly higher than singleton pregnancies（50.7%）（OR1.592,95%CI 1.228~2.062,P〈0.001）.Logistic regression analysis showed that for singleton pregnancies,the risk factors were gestational age34weeks,the elderly,BMI≥25before pregnancy,no antenatal care,IVF,ICP,GDM,renal disease（P〈0.05）;for twin pregnancies,risk factors were gestational age34weeks,IVF,ICP（P〈0.05）.Conclusions：For severe preeclampsia,the risk of adverse outcomes in twin pregnancies is significantly higher than singleton pregnancies.The risk factors for singleton pregnancies were gestational age〈34weeks,age,BMI≥25before pregnancy,no antenatal care,IVF,comorbidities（ICP,GDM,kidney disease）;for twin pregnancies were gestational age34weeks,IVF and ICP.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2015年第10期771-775,共5页
Journal of Practical Obstetrics and Gynecology
基金
四川省科技厅科技支撑计划项目(编号:2013SZ004)
关键词
重度子痫前期
单胎妊娠
双胎妊娠
高危因素
不良结局
Severe preeclampsia
Singleton pregnancies
Twin pregnancies
Risk factors
Adverse outcomes
