血管生成失衡与子痫前期关系的研究新进展被引量：1

导出

摘要子痫前期是妊娠期高血压疾病的一种类型,以广泛的内皮损伤为特征,其具体发病机制尚不明确。胎盘损伤普遍被认为是子痫前期发病的根源。近年越来越多的研究表明,血管生成因子和抗血管生成因子两者的生成失衡在胎盘损伤的发病机制中扮演着重要角色。血管/抗血管生成因子与子宫动脉多普勒血流监测等指标联合可有效提高对子痫前期预测的准确度和诊断的可靠性。目前一些研究者尝试从抗血管生成失衡方面着手治疗子痫前期,这将为今后的治疗拓展新方向。

作者陈学琳苏放明

机构地区暨南大学第二临床医学院深圳市人民医院

出处《现代妇产科进展》 CSCD 北大核心 2015年第8期624-627,共4页 Progress in Obstetrics and Gynecology

关键词子痫前期血管生成因子抗血管生成因子

分类号 R714.244 [医药卫生—妇产科学]

引文网络
相关文献

参考文献28

1Hutcheon JA, Lisonkova S, Joseph K. Epidemiology of pre- eclampsia and the other hypertensive disorders of pregnan- cy[ J]. Best Pract Res Clin Obstet Gynaeeol, 2011,25 (4) :391-403.
2Steegers EA, Von Dadelszen P, Duvekot J J, et al. Pre-ec- lampsia [ J ]. Lancet, 2010,376 (9741 ) : 631-644.
3Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFhl) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia [ J ]. J Clin Invest, 2003,111 ( 5 ) :649.
4Redman CW, Sargent IL. Latest advances in understanding preeclampsia [ J ]. Science ,2005,308 ( 5728 ) : 1592-1594.
5Staff AC, Benton SJ, Von Dadelszen P, et al. Redefining preeclampsia using placenta-derived biomarkers [ J ]. Hy- pertension ,2013,61 (5) :932-942.
6Roberts JM, Bell MJ. If we know so much about pre- eelampsia,why haven't we cured the disease? [J]. J Re- prod Immuno1,2013,99 ( 1 ) : 1-9.
7Burton G, Woods A, Jauniaux E, et al. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplaeental blood flow during human pregnancy [ J ]. Placenta,2009,30 (6) :473-482.
8Rodesch F, Simon P, Donner C, et al. Oxygen measure- ments in endometrial and trophoblastic tissues during ear- ly pregnancy [ J ]. Obstet Gynecol, 1992,80 ( 2 ) : 283-285.
9Llurba E, Crispi F, Verlohren S. Update on the Pathophysi- ological Implications and Clinical Role of Angiogenic Fac- tors in Pregnancy[J]. Fetal Diagn Ther,2015, (2) :81-92.
10董微,许群星,韩玉环,尹利荣,张立军,华绍芳.可溶性endoglin对人脐静脉内皮细胞产生一氧化氮及其合成酶磷酸化水平的影响[J].中华围产医学杂志,2011,14(11):682-687. 被引量：1

二级参考文献12

1武海英,张菊新,张予辉.妊娠高血压综合征患者血液VEGF、TNF及胎盘NO含量测定[J].郑州大学学报（医学版）,2005,40(1):83-85. 被引量：4
2Fiorucci S, Distrutti E, Mencarelli A, et al. Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy) benzoicacid 3 (nitrooxymethyl) phenyl ester (NCX 4016) (NO- aspirin ) on neutrophil endothelial cell adherence. J Pharmacol Exp Ther, 2004,309 : 1174-1182.
3Myatt L, Webster RP. Vascular biology of preeclampsia. J Thromb Haemost, 2009,7 : 375-384.
4Chedraui P,Lockwood CJ,Schatz F, et al. Increased plasma soluble fms like tyrosine kinase 1 and endoglin levels in pregnancies complicated with preeclampsia. J Matern Fetal Neonatal Med, 2009,22 : 565 570.
5Venkatesha S,Toporsian M,Lam C, et al. Soluble endoglin contributes to the pathogenesis ot" preeelampsia. Nat Med, 2006,12 =642-649.
6Levine R J, Maynard SE,Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med, 2004, 350:672-683.
7Sandrim VC, Palei AC, Metzger IF, et al. Nitric oxide formation is inversely related to serum levels o{ antiangiogenic factors soluble fms-like tyrosine kinase 1 and soluble endogline in preeclampsia. Hypertension, 2008, 52: 402-407.
8Toporsian M,Gros R, Kabir MG, et al. A role for endoglin: ineoupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res, 2005,96 : 684-692.
9朱毓纯,孙瑜,杨慧霞,廖秦平.孕妇血清中可溶性endoglin水平变化与重度子痫前期及子痫患者发病的关系[J].中华妇产科杂志,2009,44(2):91-93. 被引量：12
10张立军,韩玉环,吴莹.妊娠晚期孕妇血清可溶性endoglin水平与子痢或子痢前期的关系[J].中华围产医学杂志,2009,12(6):401-403. 被引量：5