摘要
子痫前期是导致全球孕产妇和围生儿发病和死亡的主要原因之一。子痫前期的病因至今尚未明确,但是其临床表现已证实与血循环中高水平的抗血管生成因子有关,这些抗血管生成因子是由胎盘产生的,包括可溶性血管内皮生长因子受体1(sFlt1)、可溶性Endoglin(sEng)等。血循环中sFlt1、sEng等抗血管生成因子的水平在临床症状出现前即已改变,为子痫前期的筛选、预测、诊断、治疗提供了新的思路。
Preeclampsia is a major cause of maternal and fetal morbidity in the world.Although the etiology of preeclampsia is still unclear,the clinical phenotypes of preeclampsia have been demonstrated to be related to high circulating levels of anti-angiogenic proteins secreted by the placenta such as soluble Fms-like tyrosine kinase 1（sFlt1）and soluble endoglin（sEng）.Alterations in circulating sFlt1 and sEng precede the onset of clinical disease,thereby provide new strategies for screening,early detection,diagnosis and future therapy of preeclampsia.
出处
《医学综述》
2011年第16期2427-2430,共4页
Medical Recapitulate
