摘要
目的:探讨S100A14与基质金属蛋白酶-2(MMP-2)在卵巢高分化黏液性癌中的表达情况及两者之间的相关性。方法:免疫组化法检测23例正常卵巢组织、21例交界性卵巢黏液性肿瘤、75例卵巢高分化黏液性癌中S100A14与MMP-2的表达。结果:S100A14和MMP-2表达量在正常卵巢组织、交界性卵巢黏液性肿瘤、卵巢癌中的表达均呈递增趋势,两两比较差异均有统计学意义(P<0.05)。卵巢黏液性癌中,S100A14蛋白表达量与FIGO分期、有无淋巴结转移有关(P<0.01);MMP-2蛋白表达量与FIGO分期有关(P<0.01),而与淋巴结转移无关(P=0.342)。S100A14与MMP-2在卵巢黏液性癌中的表达呈正相关(P<0.01)。结论:S100A14与MMP-2表达升高与卵巢黏液性癌的发生、进展、早期转移相关,有可能成为治疗卵巢癌的新靶点和评估预后的有力指标。
Objective：To investigate the expressions of S100A14 and MMP-2 in high differentiation of ovarian mucinous carcinoma and evaluate their relationship. Methods：The ex-pressions of S100A14 and MMP-2 were examined by immunohistochemistry analysis in tissue microarrays which contains three kinds of tissues：normal ovarian tissues（23 cases）,ovarian borderline mucinous neoplasm tissues（21 cases）,high differentiation of ovarian mucinous carci-noma tissues（75 cases）. Results：The expressions of S100A14 and MMP-2 demonstrate a rising trend in the three kinds of tissues, while there were statistical difference （ P 〈 0. 05 ）. The S100A14 and MMP-2 expressions in mucinous ovarian adenocarcinoma tissue were obviously associated with FIGO stage（P〈0. 01）. S100A14 expression was significantly higher in tissues with lymph node metastasis than those without lymph node metastasis in ovarian mucinous carci-noma （P〈0. 01）. MMP-2 expression was higher（P〈0. 05）in lymph node-positive tissues than negative tissues among the early stage ovarian carcinoma（FIGO stage I ～ II）,however,its ex-pression has no relationship with lymphatic metastasis in the high stage ovarian carcinoma（FI-GO stage III ～ IV） （ P = 0. 342）. There was significant positive correlation between S100A14 and MMP-2 in high differentiation of ovarian mucinous carcinoma （ P 〈 0. 01）. Conclusion：S100A14 and MMP-2 may pay responsibility for the process of carcinogenesis,progression and lymphatic metastasis. S100A14 and MMP-2 may be useful targets for treatment of ovarian carci-noma and a powerful index to estimate prognosis.
出处
《现代妇产科进展》
CSCD
北大核心
2015年第8期602-604,共3页
Progress in Obstetrics and Gynecology
