摘要
新生儿坏死性小肠结肠炎（neonatal necrotizing enterocolitis，NEC）是造成早产儿死亡的主要原因之一。目前发现，NEC最重要的病因发病机制是小肠结构和免疫不成熟。益生菌可通过保持或供应新生儿肠成熟和稳定所需的共生菌群，控制过度炎症反应、减少凋亡、促进和维护肠黏膜的屏障功能而保护未成熟的肠道，因而可预防或限制NEC的严重程度。口服益生菌可作为NEC的预防保护策略之一。
Neonatal necrotizing enterocolitis （NEC）is a major cause of morbidity and mortality in premature infants. The most important etiology in the pathogenesis of NEC is structural and immunological intestinal immaturity. Probiotic bacteria prevent or limits disease propagation in NEC. The unique characteristics of developing intestinal epithelia focusing on gut development and colonization as well as the inflammatory propensity of immature epithelia are highlighted in this paper. Additionally ,potential mechanisms of beneficial probiotic inter- action with immature intestinal epithelia including immunomodulation, upregulation of cytoprotective genes, pre- vention and regulation of apoptosis and maintenance of barrier function are reviewed. Probiotics may restore or supply essential bacterial strains needed for gut maturation and homeostasis. Oral administration of probiotics has been suggested as a promising strategy for prevention of NEC.
出处
《国际儿科学杂志》
2015年第5期514-518,共5页
International Journal of Pediatrics
基金
世界健康基金会项目发展基金项目（PH05531-01）
