摘要
建立了测定水基胶中3种异噻唑啉酮的液相色谱-串联质谱（LC-MS/MS）方法。水基胶样品经水萃取、离心后进行LCMS/MS分析,内标法定量。结果表明：MI、CMI在浓度范围2.5～250 ng/m L、BIT在浓度范围5～500 ng/m L内,线性关系良好（R2≥0.9996）,3个加标水平的加标回收率在96.3%～109.6%之间,平均相对标准偏差（RSD）在1.5%～6.7%之间,方法的检出限（LOD）和定量限（LOQ）分别为0.011～0.015 mg/kg和0.035～0.051 mg/kg。该方法适用于水基胶中MI、CMI、BIT的快速测定。
A method for determining 3 isothiazolinone preservatives in water-based adhesive by high performance liquid chromatographytandem mass spectrometry（LC-MS/MS） was developed.The sample was extracted with water,centrifugated,and then analyzed by LCMS/MS and quantified by internal standard method.Results showed that：the linear relationship was good with determination coefficients R^2 ≥ 0.9996 in the MI and CMI concentration range of 2.5～250 ng/m L and in the BIT concentration range of 5～500 ng/m L.The recoveries of standard addition ranged from 96.3% to 109.6% with relative standard deviation（RSD） of 1.5%～6.7%.The limit of detection was between 0.011 and 0.015 mg/kg,and that of quantification was between 0.035 and 0.051 mg/kg.It was concluded that this method was suitable for the determination of 3 isothiazolinone preservatives in water-based adhesive.
出处
《中国烟草学报》
EI
CAS
CSCD
北大核心
2015年第4期7-13,共7页
Acta Tabacaria Sinica
