摘要
目的观察支气管哮喘患儿黄芪颗粒治疗前后CD4+CD25+CD127-调节性T细胞(Treg细胞)、CD3+CD4+CD195+辅助性T细胞(Th1细胞)和CD3+CD4+CD30+辅助性T细胞(Th2细胞)的变化情况,为临床诊疗提供参考。方法将90例初发哮喘的患者随机分为2组,黄芪组45例和对照组45例,黄芪组在常规治疗基础上加用黄芪颗粒,对照组为常规治疗。治疗3个月随访,观察2组的疗效和外周血中调节性T细胞、Th1细胞和Th2细胞的数量变化。结果黄芪组中,与治疗前相比,治疗后的哮喘患儿Treg细胞和Th2细胞数量均显著下降(P<0.05),Th1细胞数量显著上升(P<0.05)。对照组中,与治疗前相比,治疗后的哮喘患儿Treg细胞数量显著下降(P<0.05)。与对照组治疗后相比,黄芪组治疗后哮喘患儿外周血中Treg细胞和Th2细胞数量均显著下降(P<0.05),Th1细胞数量显著上升(P<0.05)。结论黄芪颗粒有着调节Th1细胞和Th2细胞平衡的作用,在细胞免疫和体液免疫上对哮喘的治疗有一定的效果,并且黄芪颗粒和西药联合治疗哮喘效果更显著。
Objective To observe the changes in proportion of CD4＋ CD25＋ CD127- regulatory T cells（Treg cell）, CD3 ＋ CD4＋ CD195 ＋ helper T cell（Thl cell）, CD3 ＋ CIM＋ CD30＋helper T cell（Th2 cell ） in children with asthma receiving huangqi granule, and to offer clinical information for diagnose and treatment. Methods Total 90 cases of primary asthma were randomly divided into huangqi group and control group with 45 cases in each group. The huangqi group re- ceivedhuangqi granule on the basis of conventional therapy, while the control group received conventional treatment. The changesof Treg cells,Thl cells and Th2 cell sbefore and after the treatment in both groups were observed. Results In thehuangqi group,the count of Treg cells and Th2 cells significantly decreased after the treatment （P 〈 0.05 ） ,but Thl cells increased significantly （P 〈 0.05 ）. In the control group, the count of Treg cells significantly decreased after the treatment （ P 〈 0.05 ）. Between the two group, the count of Treg cells and Th2 cells in thehuangqi group decreased （ P 〈 0.05 ） and Thl cells increased especially significant（P 〈 0.05） when compared with the control group. Conclusion The huangqigranule can adjust the balance between the Thl cells and Th2 cells,which had a certain effect in treatment of asthmath- rough the cellular immunity and humoral immunity. Huangqi granule combined with western medicine had more significant effect on asthma.
出处
《中华全科医学》
2015年第10期1582-1584,共3页
Chinese Journal of General Practice
基金
浙江省卫计厅科技项目(JSW2013-B031)
