摘要
目的 研究氯氮平的 2周症状改善是否能预测 4周疗效。方法 给 40例精神分裂症病人予氯氮平治疗 ,在治疗 2～ 4周末剂量固定为 (30 9± 83)mg/d ,治疗 2和 4周末分别评定阳性和阴性症状量表 (PANSS)。结果 2与 4周末的PANSS总分减分率之间有极显著相关性 (r =0 .7334 ,df=39,P <0 .0 1) ,2周末PANSS总分减分率≥2 0 %的病人其 4周显效率 (12 / 2 3)比 <2 0 %的病人其 4周显效率 (0 / 17)显著为高 (P =0 .0 0 0 2 42 )。结论 氯氮平治疗 2周末症状改善 2 0 %以上者 ,到 4周末约 5 0 %的病人显效 ,而治疗 2周末症状改善不足 2 0 %者 ,到 4周末几乎无显效的可能性。
Objective To explore whether response at 14th day can predict response at 28th day in schizophrenics taking clozapin.Method It was fixed dose as(309±83)mg/d from 14th day to 28th day and was estimated Positive and Negative Syndrome Rating Scale (PANSS) at baseline,treated 14th and 28th day,respectively,in 40 inpatients with schizophrenia taking clozapine.Results There was a very significant positive correlation between PANSS total score subtractive score rate at 14th day and those at 28th day(r=0.7334,df=39,P<0.01).It was significant higher rate of predominant improvement at 28th day in patients with PANSS total score subtractive score rate≥20% at 14th day than patients with PANSS total score subtractive score rate<20% at 14th day (12/23 versus 0/17,P=0.000242<0.001).Conclusion It was approximately 50% rate of predominant improvement at 28th day in patients with symptom improvement ≥20% at 14 day,whereas it was nearly impossible for predominant improvement at 28th day in patients with symptom improvement <20% at 14th day.
出处
《四川精神卫生》
2002年第3期129-131,共3页
Sichuan Mental Health
关键词
氯氮平
早期反应
预测
后期疗效
Clozapine Early response Predict Later response
