摘要
目的依据抗菌药物的PK/PD理论,应用蒙特卡洛模拟评价氟喹诺酮类药物在治疗结核性脑膜炎时不同给药方案的疗效。方法对莫西沙星、左氧氟沙星和环丙沙星各口服给药方案治疗野生型结核分枝杆菌(MIC≤1μg/m L)的效果进行蒙特卡洛模拟,比较各方案的累积反应分数CFR以评价疗效。结果口服莫西沙星800mg qd及左氧氟沙星500mg bid、750mg qd的给药方案治疗野生型结核分枝杆菌的CFR>90%,为有效治疗方案;而莫西沙星400mg qd及环丙沙星500mg bid、750mg bid的给药方案CFR<90%,不作为推荐给药方案。结论对于结核性脑膜炎,莫西沙星800mg qd、左氧氟沙星750mg qd为各药的最优给药方案;环丙沙星对结核分枝杆菌的效果不理想。
Objective To estimate and optimize the dosage regimens of fluoroquinolones tbr tuberculousmeningitis with the utilization of Monte Carlo simulation （MCS） based on PK/PD. Methods MCS model wasused to simulate different oral dosage regimens against wild-type Mycobacterium tuberculosis（MIC≤ 1 pg/mL）, andcompare the CFRs of those regimens. Results The CFRs of 800mg qd moxifloxacin and 500mg bid, 750mg qdlevofloxacin against wild-type Mycobacterium tuberculosis achieved 90%, so those regimens were effective. But theCFRs of 400mg qd moxifloxaein and 500mg bid, 750mg bid ciprofloxacin were all less than 90%, so those regimenswere not recommended. Conclusion For tuberculous meningitis, the optimal dosage regimens of moxifloxacinand levofloxacin were 800mg qd and 750mg qd, respectively. But the 2 dosage regimens of ciprofloxacin were bothineffective against Mycobacterium tuberculosis.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2015年第8期626-629,共4页
Chinese Journal of Antibiotics
基金
天津市卫生局攻关课题(No.13KG108)
