摘要
目的总结我国2010年临床男性患者尿标本分离细菌的分布与耐药状况。方法常规方法培养分离男性尿标本中的细菌,按照美国实验室与临床标准化研究所(CLSI)2010版规定,用纸片法、微量稀释法或E-test法,测定细菌药物敏感性,用WHONET5.6软件进行菌种分布及药物敏感性分析。结果全国129家医院2010年度共从男性尿标本中分离出15833株细菌,排在前4位的依次是大肠埃希菌(4858株,30.7%)、粪肠球菌(1558株,9.8%)、屎肠球菌(1503株,9.5%)和铜绿假单胞菌(1264株,8.0%)。大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌、产酸克雷白杆菌对亚胺培南的耐药率分别为5.7%,10.7%,11.8%和6.7%;对左氧氟沙星的耐药率分别为71.8%,51.5%,47.5%和41.7%。铜绿假单胞菌和鲍曼不动杆菌对亚胺培南、阿米卡星和左氧氟沙星的耐药率分别为18.3%,10.7%,30.2%和52.2%,44.4%,56.1%。屎肠球菌对万古霉素和替考拉宁的耐药率为5.6%和3.3%,粪肠球菌对万古霉素和替考拉宁的耐药率为1.0%和0.8%。结论男性尿路感染主要致病菌仍以大肠埃希菌为主,对喹诺酮类耐药率仍较高,肠球菌中万古霉素耐药率仍处于较低水平。
Objective To investigate the bacterial distribution and re- sistance to antibiotic in urinary tract infections in male in China in 2010. Methods All the clinical stains isolated and the susceptibility tests of the isolates were performed by 129 hospitals around China from January 1, 2010 to December 31, 2010. Disc diffusion test, MIC test and E - test were used to detect the antimicrobial sensitivity according to Clinical and Laboratory Standards Institute （CLSI, 2010） manual and the suscep- tibility data were processed with WHONET 5.6 software. Results A to- tal of 15833 pathogenic strains were collected from urine specimen of male, which included E. coli 4858 strains （30.7%）, E. fnecalis1558 strains （9.8%）, E. faecium 1503 strains （9.5%） and P. aeruginosa 1264 strains （8.0%）. The proportions of E. coli, K. pneumonia, E. cloaecae and K. oxytoca strains resistant to imipenem were 5.7%, 10.7% ,11.8% and 6. 7%, respectively. The proportions ofE. coli, K. pneumonia, E. cloaecae and K. oxytoca strains resistant to levofloxacin were 71.8%, 51.5%, 47.5% and 41.7% , respectively. The proportions of P. aeruginosa and A. baumannii strains resistant to imipenem were 18.3% and 52. 2%. 5.6% and 3.3% of E. faecium were resistant to vancomycin and teicoplanin, respectively. 1.0% and 0. 8% of E. faecalis were resistant to vancomyicin and teicoplanin, respectively. Conclusion E. coli and Enterococcus were predominant organism in male urinary tract infections in China. These data present important information for the proper treatment of urinary tract infections and will serve as a useful reference for periodic surveillance studies in the future.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2011年第12期905-912,共8页
The Chinese Journal of Clinical Pharmacology
关键词
尿路感染
男性
细菌耐药
抗菌药物
urinary tract infection
male
drug resistance
bacterial
