摘要
目的研究左氧氟沙星口服给药和局部介入治疗用药量的依据，为临床提供参考。方法采用高效液相色谱法测定血清中左氧氟沙星浓度，在体外检测MIC、MBC、时间-杀菌及耐药梯度等试验。结果8例肺结核患者血峰浓度于1．22小时到达（4．52±0．72）mg／L，1次给药24小时后最低血药浓度为（0．52±0．26）me／L，表观分布容积V／FC为（77．48±8．33）L。该药MIC、MBC值为0．5mg／L、1mg／L，耐药梯度范围在0．5-48mg／L。结论耐药肺结核病人服用左氧氟沙星，应注意24小时体内血药浓度维持在最低杀菌浓度MBC之上，介入治疗用药浓度应在48mg／L以上。
Objective To study the appropriate dose of Levofloxacin-methane sulfonic acid （LFXMSA） given orally and through interventional approach. Methods The concentration of LFXMSA in serum were measured by HPLC. MIC, MBC, time-bactericide gradient and time-drug resistance gradient were detected in vitro. Results The peak concentration of LFXMSA in serum of 8 patients are 4.52 ＋ O. 72mg/L in 1.22 hours, and the minimal concentration of LFXMSA in serum was 0.52 ± 0.26mg/L after patients were given a single dose within 24 hours. The apparent volume of distribution was 77.48 ± 8.33 L. The value of MIC and MBC were 0.5mg/L and lmg/L The range of drug resistance gradient was 0.5mg/L to 48mg/L. Conclusion The dosage and internal time of LFXMSA in patients with pulmonary tuberculosis would be controlled, the concentration of LFXMSA in serum within 24 hours should be maintained above the minimal concentration of bactericide, and the dosage of LFXMSA in interventional therapy should he above 48mg/L.
出处
《中国医刊》
CAS
2006年第4期37-38,共2页
Chinese Journal of Medicine
关键词
左氧氟沙星
耐药肺结核
药效学
治疗
Levofloxacin-methane sulfonic acid
MDR-TB
pharmacodynamics
