摘要
目的:系统评价中医药相关疗法对颈动脉粥样硬化斑块的临床疗效。方法:计算机检索The Cochrane Library、Pub Med、CBM、CNKI、Wan Fang Data及VIP,收集有关中医药治疗颈动脉粥样硬化斑块的随机对照试验(RCT),检索时限从建库至2014年8月,由两位研究者根据纳入及排除标准独立筛选文献、提取信息及评价纳入文献的方法学质量后,采用软件Rev Man 5.2.9进行Meta分析。结果:最终纳入10个RCT,共计1006例患者,干预措施治疗组为中医药相关疗法,对照组均为常规西药治疗。Meta分析结果显示:与常规西药用药相比,中医药干预组能显著改善临床证候[OR=2.08,95%CI(1.50,9.55),P=0.004];颈动脉内中膜厚度影响方面,中医药较单纯西药治疗有效,其差异有统计学意义[MD=-0.06,95%CI(-0.10,-0.03),P=0.000 6];对降低硬化斑块体积/面积,中医药干预组也较对照组明显(P<0.000 01)。结论:在治疗颈动脉粥样硬化斑块方面,中医药干预组的疗效优于常规西药用药组。因纳入研究质量较低,数量所限,故上述结论仍需开展更多大样本高质量的RCT加以验证。
Objective：To evaluate the clinical efficacy of TCM therapy on the carotid atherosclerotic plaque.Methods：Search The Cochrane Library, PubMed, CBM, CNKI, WanFang Data and VIP and collect information of randomized controlled trial （ RCT） about Chinese medicine treatment for carotid atherosclerotic plaque, building a database to re-trieve the time to August 2014 .Two reviewers independently screened the literatures based on inclusion and exclusion criteria,and extracted information and evaluation methods including studies after methodology quality by use of software RevMan 5.2.9 Meta-analysis.Results：Including 10 RCT, totally 1006 cases of patients, the treatment group was trea-ted with interventions of Chinese medicine-related therapy,and the control group was treated with conventional western medicine.Meta -analysis showed that： Compared with conventional western medicine treatment, TCM intervention could significantly improve the clinical syndromes [OR=2.08,95%CI （1.50,9.55）, P=0.004];as to the internal carotid artery thickness impacts, TCM was more effective compared with western medicine alone,and the difference was statistically significant [MD=-0.06,95%CI （-0.10, -0.03）,P=0.000 6]：as to reducing plaque volume/area, traditional Chinese medicine in the intervention group was more significant compared with the control group （ P 〈0.000 01）.Conclusion：In the treatment of carotid atherosclerotic plaque, the efficacy of Chinese medicine in the inter-vention group is better than that of the conventional western medicine group.Due to the poor quality and the quantity limitation,the above conclusions still need to be verified through more large samples of high-quality RCT.
出处
《中医药学报》
CAS
2015年第3期20-24,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金面上项目(No.81373716)
湖南省科技计划项目(No.2013SK3090)
国家中医药管理局推广项目
关键词
中医药
颈动脉粥样硬化斑块
随机对照试验
META分析
IMT
Chinese medicine
Carotid atherosclerotic plaque
IMT
Randomized controlled trial
Meta-analysis
