摘要
目的观察地黄饮子治疗颈动脉粥样硬化斑块的疗效及对血内皮素(ET)、丙二醛(MDA)、C反应蛋白(CRP)的影响。方法将100例患者随机分为两组,治疗组50例患者采用地黄饮子汤剂治疗,对照组50例患者采用舒降之、肠溶阿司匹林治疗。治疗前、后分别测定两组患者的ET、MDA、CRP及颈动脉管腔直径(CCAD)、内中膜厚度(IMT)、收缩期峰值血流速度(SV)、舒张期峰值血流速度(DV)、阻力指数(R I)和搏动指数(PI),并观察两组患者的斑块数量变化及症状改善情况。结果经地黄饮子治疗后,两组患者的ET、MDA、CRP均较治疗前明显降低;患者颈动脉斑块体积缩小或消失;CCAD增加、IMT变薄、SV增加、DV增加、R I减少、PI增加,临床症状及体征消失或改善,但与对照组间差别无显著性意义(P>0.05)。结论地黄饮子治疗颈动脉粥样硬化斑块疗效明显,能明显降低ET、MDA、CRP的含量,且无毒副作用。
Objective To observe the effect of Dihuangyinzi on ET, MDA, CRP in patients with Carotid Atherosclerotic Plaque. Methods 100 patients were randomly divided into two groups, 50 patients with Carotid Atherosclerotic Plaque in treatment group were treated by Dihuangyinzi, 50 patients in control group were treated by Simvastatin and Aspirin, the ET, MDA, CRP, CCAD, IMT, SV, DV, RI, PI, plaque volume, plaque quality, symptoms, signs, blood viscosity and blood fat were recorded before and after treatment. Results After the treatment of Dihuangyinzi, the patients＇ ET, MDA, CRP decreased obviously. CCAD increasing, IMT thinning, SV increasing, DV increasing, RI reducing, PI increasing. Clinical symptoms and signs disappearing or improving, there was no significant difference between the two groups （ P 〉0. 05）. Conclusion Dihuangyinzi is useful to treat Carotid Atherosclerotic Plaque and obviously drop of blood ET, MDA, CRP without any side effect.
出处
《中国全科医学》
CAS
CSCD
2006年第4期335-337,共3页
Chinese General Practice
