摘要
目的：探讨神经节苷脂联合高压氧治疗新生儿缺氧缺血性脑病（HIE）的疗效以及对血清神经元特异性烯醇化酶（NSE）的影响。方法将新生儿科收治并确诊的92例 HIE 患儿采用随机数字表法分为两组，每组46例，均给予常规综合治疗，均于入院第3天加用胞磷胆碱治疗，另外观察组在此基础上加用神经节苷脂联合高压氧治疗，观察并比较两组临床治疗效果及治疗前后新生儿神经行为测定（NBNA）评分和血清NSE 水平。结果观察组总有效率为93．48％，显著高于对照组的76．09％（χ2＝10．02，P ＜0．05）；观察组治疗后 NBNA 评分为（38．92±4．10）分，显著高于治疗前（t ＝8．00，P ＜0．05）和对照组（t ＝6．89，P ＜0．05）；而血清 NSE 水平为（9．56±2．03）μg／L，显著低于治疗前（t ＝8．31，P ＜0．05）和对照组（t ＝7．12，P ＜0．05）。结论神经节苷脂联合高压氧治疗 HIE 疗效显著，可明显降低血清 NSE 水平，改善患者神经功能，具有较好的临床应用价值。
Objective To investigate the curative effect of ganglioside combined with hyperbaric oxygen in treatment of neonatal hypoxic ischemic encephalopathy （HIE）and its influence on serum neuronspecific enolase （NSE）.Methods 92 cases of children with HIE were randomly divided into two groups,each group in 46 cases. They were all given routine therapy,and added the citicoline for treatment at third day after being hospitalized,and the observation group were treated with ganglion ganglioside combined with hyperbaric oxygen on the basis of that.Clinical treatment effect and neonatal behavioral neurological（NBNA）scores,serum neuron specific enolase （NSE）levels of the two groups before and after treatment were observed and compared.Results The total effective rate of the obser-vation group was 93.48%,which was significantly higher than 76.09% of the control group （χ2 =10.02,P 〈0.05）;NBNA score of the observation group after treatment were （38.92 ±4.10）points,which was significantly higher than that before treatment （t =8.00,P 〈0.05）and the control group （t =6.89,P 〈0.05）;while its serum NSE was （9.56 ± 2.03）μg/L,which was significantly lower than before treatment（t =8.31,P 〈0.05）and the control group（t =7.12, P 〈0.05）.Conclusion The ganglioside combined with hyperbaric oxygen therapy has a significant effect for hypoxic ischemic encephalopathy,which can significantly decrease the serum NSE level,improve neurological function and has a better clinical application value.
出处
《中国基层医药》
CAS
2015年第13期1980-1982,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
神经节苷脂
高压氧
缺氧缺血性脑病
新生儿
神经元特异性烯醇化酶
gangliosides
hyperbaric oxygen
hypoxic ischemic encephalopathy
Serum neuron specific enolization enzymes
