摘要
目的:观察神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的疗效及对TNF-α和IL-6的影响。方法:将78例HIE患儿随机分为两组,对照组39例仅采用常规治疗,观察组39例在常规治疗基础上应用神经节苷脂治疗,比较观察两组的临床效果、TNF-α和IL-6指标的变化。结果:观察组的总有效率为92.3%,对照组的总有效率为74.4%,两组比较差异有统计学意义(P<0.05)。观察组肌张力、反射和意识恢复天数均明显小于对照组,两组比较差异有统计学意义(P<0.05)。两组治疗后TNF-α和IL-6水平明显下降,与治疗前比较差异有统计学意义(P<0.05)。并且,观察组治疗后TNF-α和IL-6水平明显低于同期对照组(P<0.05)。结论:神经节苷脂对HIE进行治疗能够明显提高临床疗效,缩短张力、反射和意识恢复时间,降低血清TNF-α、IL-6水平,值得在临床推广应用。
Objective： To observe the therapeutic effect of ganglioside in treatment of neonatal hypoxic isehemic encephalopathy （HIE） and its effect on TNF -a and IL -6. Methods： 78 neonates with HIE were divided into two groups randomly, 39 neonates in control group were treated with routine treatment, the other 39 neonates in observation group were treated with ganglioside on the basis of routine treatment, the clinical efficacies, the changes of TNF - a and IL - 6 in the two groups were compared and observed. Results ： The total effective tales in observation group and control group were 92. 3% and 74. 4%, respectively, there was significant difference between the two groups （P 〈 0. 05 ） . The recovery times of muscle tension, reflection and awareness in observation group were significantly shorter than those in control group （P 〈 0. 05 ） . In the two groups, the levels of TNF - a and IL - 6 after treatment decreased significantly, there was significant difference before and after treatment （P 〈0. 05） , After treatment, the levels of TNF-a and IL- 6 in observation group were significantly lower than those in control group （P 〈 0. 05 ） . Conclusion ： Ganglioside can improve the clinical efficacy significantly in treatment of HIE, shorten the recovery times of muscle tension, reflection and awareness, reduce the serum levels of TNF - a and IL - 6, which is worthy to be popularized in clinic.
出处
《中国妇幼保健》
CAS
北大核心
2011年第25期3908-3910,共3页
Maternal and Child Health Care of China
