摘要
目的：探讨急性心肌梗死（AMI）合并2型糖尿病（T2DM）患者长正五聚蛋白3（PTX3）、N 末端脑钠肽前体（NT-ProBNP）水平的变化及在预后判断中的意义。方法选择63例初发型 AMI 合并 T2DM患者为研究对象（观察组），另外选取同期住院的80例初发型 AMI 未合并糖尿病的患者作为对照组，分别用酶联免疫吸附法（ELISA）及电化学发光法检测血浆 PTX3、NT-ProBNP 浓度；观察患者住院期间及出院12个月内主要心脏不良事件（MACE）发生情况，对观察组中 PTX3、NT-ProBNP 浓度与 MACE 发生情况的相关性进行分析。结果观察组 PTX3、NT-ProBNP 浓度[（8．95±5．06）ng／mL，（1609±1049）pg／mL]显著高于对照组[（7．03±3．70）ng／mL，（1198±809）pg／mL]（P ＝0．010，P ＝0．009）；观察组发生 MACE 的例数（26例）显著高于对照组（15例）（P ＝0．003）；观察组中 MACE 患者的 PTX3、NT-ProBNP 浓度[（10．98±5．45）ng／mL，（2007±1097）ng／mL]显著高于未发生 MACE 患者[（7．53±4．28）ng／mL，（1330±930）ng／mL]（P ＝0．007， P ＝0．010），MACE 患者中死亡者的 PTX3、NT-ProBNP 浓度[（13．88±6．84）ng／mL，（2596±1333）ng／mL]显著高于未死亡者[（9．18±3．52）ng／mL，（1639±751）ng／mL]（P ＝0．029，P ＝0．023）。结论AMI 合并 T2DM患者较未合并糖尿病患者可能发生了更为强烈的炎性反应及心肌损害，有着更差的预后；PTX3、NT-ProBNP联合检测在患者的心肌损害程度及预后判断中具有重要意义。
Objective To investigate the changes of PTX3,NT -ProBNP level and the correlation between them and the prognosis of the patients with AMI combined T2DM.Methods 143 patients with primary AMI were enrolled,of which 63 patients with type 2 diabetes （observation group）and 80 patients with no diabetes （control group）.Plasma PTX3 values were measured with ELISA method and NT -ProBNP was detected by the electrochemi luminescence method.All patients were observed for the occurrence of MACE during hospitalization and 12 months after discharge.The correlation between PTX3,NT -ProBNP concentration and occurrence of MACE in observation group were analyzed.Results The PTX3,NT -ProBNP concentration[（8.95 ±5.06）ng/mL,（1 609 ±1 049）pg/mL]in the observation group were significantly higher than those in the control group[（7.03 ±3.70）ng/mL,（1 198 ± 809）pg/mL]（P =0.010,P =0.009）;The number（n =26）of patients with occurrence of MACE in the observation group was significantly higher than 15 cases in the control group（P =0.003）.In the observation group,the PTX3, NT -ProBNP concentration[（10.98 ±5.45）ng/mL,（2 007 ±1 097）ng/mL]in patients with MACE were signifi-cantly higher than those in patients without MACE[（7.53 ±4.28）ng/mL,（1330 ±930）ng/mL]（P =0.007,P =0.010）,and in MACE group,the PTX3,NT -ProBNP concentration[（13.88 ±6.84）ng/mL,（2 596 ±1 333）ng/mL] in patients with death weresignificantly higher than those in patients without death[（9.18 ±3.52）ng/mL,（1 639 ± 751）ng/mL]（P =0.029,P =0.023）.Conclusion More strong chronic inflammatory reaction and serious myocar-dial injury might occur in the patients with AMI combined and T2DM,and those patients would have poorer prognosis. The combined detection of PTX3,NT -ProBNP has an important significance in evaluating of the degree of myocardial damage and the prognosis of the patients with AMI combined T2DM.
出处
《中国基层医药》
CAS
2015年第13期1974-1977,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
心肌梗死
糖尿病
2
型
利钠肽
脑
预后
Myocardial Infarction
Diabetes Mellitus, Type 2
Natriuretic Peptide, Brain
Prognosis
