摘要
目的观察急性冠脉综合征(acute coronary syndrome,ACS)患者外周血单核细胞五聚蛋白-3(pentraxin-3,PTX-3)的浓度变化,探讨其对ACS早期诊断的意义。方法将90例ACS患者分为不稳定型心绞痛(unstable angina group,UAP)组47例,急性心肌梗死(acute myocardial infarction,AMI)组43例;另外,选同期相匹配的稳定型心绞痛(stable angina group,SAP)组42例和健康体检者33名作为对照组。采用酶联免疫吸附法(ELISA)测定各组外周血单核细胞PTX-3浓度。结果 UAP组、AMI组外周血单核细胞PTX-3浓度均高于SAP组和健康对照组,差异有统计学意义(P<0.05);且AMI组明显高于UAP组,差异有统计学意义[(8.32±2.79)μg/L vs.(5.37±1.83)μg/L,P<0.01];SAP组与健康对照组比较,差异无统计学意义[(4.28±1.70)μg/L vs.(3.69±3.02)μg/L,P>0.05]。结论 ACS患者外周血单核细胞中可检测PTX-3的存在,且外周血单核细胞PTX-3浓度可以作为识别和判断ACS发作的临床指标。
Objectives To observe the concentration of peripheral blood mononuclear cell（PBMC） pentraxin-3（PTX-3）in patients with acute coronary syndrome（ACS） and to discuss its significance for early diagnosis of ACS. Methods A total of 90 patients with ACS were divided into unstable angina（UAP） group（47 cases） and acute myocardial infarction（AMI） group（43 cases）. In the same period,we selected 42 patients with stable angina pectoris（SAP） that matches the same conditions as SAP group and 33 healthy cases as control group. Concentration of PBMC PTX-3 was detected by enzyme-linked immunosorbent assay（ELISA）. Results Concentrations of PBMC PTX-3 in UAP group,AMI group were significantly higher than those in SAP group and control group（P〈0.05）. Concentration of PBMC PTX-3 in AMI group was significantly higher than that in UAP group [（8.32±2.79） μg / L vs.（5.37 ±1.83） μg / L,P〈0.01]. Concentration of PBMC PTX-3 in SAP group was not statistically different with that in control group [（4.28 ±1.70） μg / L vs.（3.69 ±3.02） μg / L,P〉0.05 ]. Conclusions PTX-3 can be detected in PBMC in patients with ACS,and PBMC PTX- 3 can be used as a clinical indicator for ACS.
出处
《岭南心血管病杂志》
2015年第1期37-39,共3页
South China Journal of Cardiovascular Diseases
基金
三亚市院地合作项目(编号:2011YD100)
关键词
冠状动脉疾病
心绞痛
心肌梗死
外周血单核细胞
五聚蛋白-3
coronary artery disease
angina
myocardial infarction
peripheral blood mononuclear cell
pentraxin-3
