摘要
喹诺酮类抗菌药物在临床中应用相当广泛,同其他抗菌药物一样,喹诺酮类也存在严重的耐药问题。质粒介导的喹诺酮类药物耐药机制(PMQR)为其耐药的重要原因,近年的研究发现PMQR主要由qnr、aac(6’)-Ib-cr、qepA和oqxAB等基因介导,这些基因介导的耐药机制及其各自的流行率存在很大差异,上述基因还能通过质粒接合而广泛传播。研究还发现上述基因与超广谱β内酰胺酶(ESBLs)等多种耐药基因存在密切联系,介导更为广泛的耐药。PMQR基因的检测技术也不断更新,新的检测技术有许多优势,可供科学研究参考。PMQR的严重性已不容忽视,需加强临床监测和合理使用抗菌药物,能有效延缓抗菌药物的抗菌周期。本文就质粒介导的喹诺酮类药物耐药机制的研究现状及进展作一综述,为临床用药提供参考。
As widely used antibacterial agents, drug resistance restricted quinolones clinical application to extreme degree. Plasmid-mediated quinolone resistance （PMQR） is one of the most important part of the resistance mechanism. Recent researchers found that PMQR is mediated by the genes including qnr, e（6＇）-Ib-cr, pA and oqxAB. The mecha- nism and prevalence of each gene is very different, and these genes could transmit through conjugation. Some researchers indicate that the PMQR genes are closely linked with other plasmid resistance genes mediated more extensive drug resistante. Some new detection with hasmany advantages can refer to scientific research. Seriousness of PMQR cannot be ignored. Strengthen clinical monitoring and rational use of antimicrobial agents is needed indeed, thus antibacterial cycle of antimicrobial agents can be effectively delayed.
出处
《西部医学》
2015年第7期1108-1112,共5页
Medical Journal of West China
基金
教育部博士点基金项目(20115132120004)
关键词
质粒
喹诺酮
耐药基因
耐药机制
Plasmid
Quinolonel Resistant genel The mechanism of drug resistance
