摘要
细菌的多重耐药已成为临床治疗的难题,其耐药机制、耐药基因的传播与转移是近年来研究的热点。近来研究表明,细菌中存在一种能捕获和表达基因的遗传单位———整合子在细菌获得耐药机制中起了重要作用。整合子编码一个整合酶负责基因盒在重组位点attⅠ和attC上的插入及切除,同时整合子也提供一个启动子(Pant)负责基因盒耐药基因的表达。整合子携带着重组的基因盒插入到转座子或接合质粒中,在不同的细菌间运动而传播耐药性,同时一个整合子可以捕获多个基因盒,对细菌多重耐药的形成起重要作用。现就整合子的结构、类型、基因盒的种类与表达及其与细菌多重耐药性的有关研究进行综述。
Antibiotic multidrug resistance has been become a tough problem in clinical practice. The mechanisms of antibiotic resistance and dissemination and transfer of antibiotic resistance genes have raised a concern study in the recent years. The recent results showed integron found among bacteria was able to capture and express alien genes, and it played an important role in the mechanisms of antibiotic resistance. The integron encodes a integrase （ Int Ⅰ ） responsible for the insertion and excision of gene cassettes at recombination site art I and attC,and also provides the promoter responsible for expression of the cassette-encoded genes. The integrons carrying recombinated cassettes are embedded in transposon or conjugative plasmids, mobilize among bacteria and spread antibiotic resistance. The integron can capture gene cassettes,it plays an important role in multiple antibiotic resistance. The present paper reviewed on the structure and classification of integrons, the categories and expression of cassettes, the relationship between the integron and multidrug resistance.
出处
《动物医学进展》
CSCD
2006年第4期29-32,共4页
Progress In Veterinary Medicine
关键词
整合子
转移
细菌
多重耐药
integron
transfer
bacteria
multidrug resistance
