摘要
目的:探讨质子泵抑制剂(PPI)治疗咽喉反流(LPR)患者声嘶症状的疗效。方法:60例以声嘶为主诉LPR患者,随机分为A、B两组:A组(30例)给予金嗓开音胶囊治疗(1.2g/次,2次/d,口服,连用3个月);B组(30例)在A组的基础上同时加用奥美拉唑治疗(20mg/次,2次/d,口服,连用3个月)。在治疗前和治疗后1、2、3个月分别记录以下数据:反流症状指数(RSI),反流体征指数(RFS)和嗓音障碍指数(VHI),比较A、B两组上述参数变化的差异。结果:60例患者治疗前RSI和RFS分别与VHI评分比较,均呈显著正相关(r=0.823,P<0.01;r=0.873,P<0.01)。与治疗前相比,B组治疗后1、2、3个月的RSI和VHI的评分变化显著高于A组,差异有统计学意义(P<0.01)。B组治疗后1、2个月的RFS评分与A组比较差异无统计学意义(t=1.128,P>0.05;t=0.376,P>0.05),但治疗后3个月RFS评分显著高于A组(t=8.307,P<0.01)。结论:PPI治疗可显著改善LPR患者的声嘶症状。
Objective：To analyze the therapeutic effect of proton pump inhibitor（PPI） on alleviation of hoarse- ness symptoms in patients with laryngopharyngeal reflux（LPR）. Method： The LPR outpatients in ENT depart- ment of our hospital（60 cases）complained of hoarseness were enrolled in the study from August of 2013 to October of 2014. All of them were randomly divided into group A and B. The individuals in group A （30 cases） taked golden voice capsule to treat for 3 months, while the individuals in group B （30 cases） raked golden voice capsule and omeprazole to treat for 3 months. The data about reflux symptom index （RSI）. reflux finding score （RFS） and voice handicap index （VHI）from the first month to the third month after treatment were recorded and compared group A with group 13. Result：The scores of RSI and RFS in patients （60 cases） before treatment were significantly correlated with their VHI （r=0.823, P〈0.01; r=0.873, P〈0. 01）. The score changes of RSI and VHI from the first to the third month after treatment in group B were significantly higher than those in group A （P〈0.01）. Meanwhile, the score changes of RFS from the third month after treatment in group B were significantly higher than those in group A （t=8. 307,P〈0. 01）, but the differences were not significant for RFS from the first to the second month after treatment between group A and group B（t=1. 128,P〉0.05;t=0. 376,P〉0.05）. Conclusion.. PPI therapy could significantly alleviate the hoarseness symptom in LPR patients.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2015年第11期997-1001,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
声嘶
咽喉反流
质子泵抑制剂
hoarseness
laryngopharyngeal reflux
proton pump inhibitor
