摘要
目的观察青春期后女性痤疮患者（25～40岁）性激素水平的改变情况。方法对入选的60例青春期后女性痤疮患者（肝经郁热型42例，阴虚火旺型18例）分别于月经周期第2—3天时采集空腹静脉血以检测其血清性激素水平，包括血清睾酮（T）、雌二醇（E2）、孕酮（P）、催乳素（PRL）、促卵泡激素（FSH）、黄体生成素（LH）、性激素结合蛋白（SHBG）、硫酸脱氢表雄酮（DHEAS），另选择30例同期在本院进行健康体检的女性志愿者或职工作为对照组。结果青春期后女性痤疮患者组DHEAS显著高于志愿者组，SHBG显著低于志愿者组（P均〈0．01）；肝经郁热型患者FSH低于阴虚火旺型，而LH、LH／FSH及PRL均高于阴虚火旺型（P均〈0．05）。结论DHEAS和SHBG异常改变与青春期后女性痤疮的发病可能有关。肝经郁热型青春期后女性痤疮患者性激素水平改变主要为LH，FSH及PRL异常。
Objective To study the changes of sex hormone levels in women aged 25 to 40 years old with post-adoles- cent acne. Methods Sixty patients with post-adolescent acne, including 42 patients with liver-meridian heat and 18 patients with yin-deficiency fire-flourishing, were enrolled in this study. 30 healthy females vol- unteers who were under routine physical examination at our hospital, and our hospital staff members served as controls. Serum levels of sex hormones, including Testosterone （T）, Estradiol （E2）, Progesterone （P）, Prolactin（PRL） , Follicle Stimulating Hormone （FSH） , Luteinizing （LH） , Sex Hormone Binding Globulin （SHBG） and Dehydroepiandrosterone Sulfate （DHEAS） were measured in the second or third day of men- strual cycle. Results DHEAS levels in patients with post-adolescent acne were significantly higher than that in the controls, while SHBG levels were significantly lower in patients than in controls（P 〈 0. O1 ） ; FSH lev- els in patients with liver-meridian heat were lower than those with yin-deficiency fire-flourishing. However, the levels of LH, LH/FSH and PRL in patients with liver-meridian heat were much higher than those with yin-deficiency fire-flourishing （P 〈 0.05 ）. Conclusion The study indicates that changes of DHEAS and SHBG are associated with the pathogenesis of females post-adolescent acne. The main changes of sex hor- mone levels in the patients with liver-meridian heat are serum LH, FSH and PRL levels.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2015年第6期572-574,共3页
The Chinese Journal of Dermatovenereology
基金
江苏省中医药局科技项目(编号LZ11152)
关键词
女性
青春期后
痤疮
性激素
Females
Post-adolescent
Acne
Sex hormone
