摘要
目的探讨女性痤疮患者血清雄激素水平的变化情况,以指导临床治疗。方法检测76例女性痤疮患者及24例同龄正常对照女性血清睾酮(T)、双氢睾酮(DHT)、游离睾酮(FT)、性激素结合球蛋白(SHBG),并对痤疮严重程度与T、DHT、FT、SHBG水平相关性进行统计学分析。结果痤疮患者组T、DHT水平高于对照组(P<0.05)。血清FT水平显著高于正常对照组(P<0.01),血清SHBG水平显著低于对照组(P<0.01)。女性痤疮患者分级后Ⅰ、Ⅱ、Ⅲ、Ⅳ级间血清雄激素水平无显著性差异(P>0.05)。结论痤疮发病与雄激素水平显著相关,与健康对照组相比,女性痤疮患者血清T、DHT、FT水平升高,血清SHBG水平降低。痤疮严重程度与雄激素水平无量效关系。
Objective To investigate the level change of serum androgen in female patients with acne vulgaris. Methods The serum levels of testosterone （T）, dihydrotestosterone （DHT）, free testosterone（FT） and sex hormone-binding globulin （SHBG） were measured by the radio-immunity method in 76 female patients with acne vulgaris and 24 normal individuals. The statistic analysis was performed for the correlation between the severity of acne and the levels of T, DHT, FF and SHBG. Results The serum levels of T and DHT in female patients with acne vulgaris were higher than that of normal controls （P〈 0.05）. The serum levels of FT in female patients with acne vulgaris were significantly higher than that of controls （P〈0.01）. The serum levels of SHBG in female patients with acne vulgaris were significantly lower than that of controls （P〈0.01）. There were no significant difference among different severity grades of female ache vulgaris patients in serum the levels of serum androgen. Conclusion These results verified the critical role that the androgen played in the pathogenesis of acne vulgaris also showed that the serum T, FT and DHT levels in the female acne vulgaris patients were higher than those in normal individuals. The serum levels of SHBG in the patients are lower than those in normal individuals. There are no significant difference between the severity of acne vulgaris and the serum levels of serum androgen.
出处
《实用医药杂志》
2009年第6期1-2,共2页
Practical Journal of Medicine & Pharmacy
关键词
女性
痤疮
性激素
Female patients Acne vulgaris Sexual hormone
