摘要
目的探讨寻常痤疮证素(辨证要素)规律及其内分泌机理。方法①采用流行病学方法调查青年学生840人。②选择70例痤疮患者为对象,15名健康人为对照,以证素辨证和性激素为指标。结果①痤疮患病率86.9%;病位证素属肝比例最大,肾次之;病性证素中属热者比例最大,阴虚次之(P<0.01)。②男、女患者的睾酮(T)值均高于正常对照组(P<0.01、P<0.05),雌二醇(E2)、卵泡刺激素(FSH)、黄体生成激素(LH)差异无统计学意义(P>0.05)。③男性患者肝郁化火型的LH/FSH显著高于心火旺盛、肺经风热、肾虚火旺型(P<0.01～P<0.05);湿热蕴脾型的LH/FSH显著高于心火旺盛和肺经风热型(P<0.05)。女性患者性激素组间差异无统计学意义(P>0.05)。结论痤疮病位以肝、肾为主,病性以热证多见,证候形成与性激素变化有关,其中T值升高可能是热证形成的物质基础。
Objective To study the rule of dialectical elements of acne and the mechanism of endocrine in acne vulgaris. Methods 840 adolescent students were investigated by epidemiologic survey. Meanwhile, the indexes of sexual hormones and TCM syndrome elements differentiation were used as norm in 70 patients with acne vulgaris, and 15 healthy persons as control. Results （1）The attack rate was 86.9%. The rate of syndrome element of the disease location, liver was the highest, and kidney was the second （P〈0.01）. The rate of syndrome element of the disease nature, heat was the highest. And the rate of yin deficiency was the second （P〈0.01）. （2）The testosterone （T） in both male and female patients was higher than that in control group （P〈0.01, P〈0.05）, while the estradial, follicle-stimulating hormone and luteinizing hormone showed no difference （P〉 0.05）. （3）In male patients, the LH/FSH in the group of fire due to liver depression was highest, and that in the group of spleen damp-heat was the second （P〈0.01, P〈0.05）. In female patients, the sexual hormones between different syndrome group showed no difference （P〉0.05）. Conclusion The location of acne is liver and kidney which mainly manifested as the heat syndrome. The syndrome is related to the changes of sexual hormones. Probably the ascending of T is the material basis of the heat syndrome.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2009年第2期73-75,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金
福建省泉州市科技三项经费资助项目(编号2004Z41)
关键词
痤疮
性激素
证素
acne vulgaris
sexual hormone
syndrome element
